This is the protocol for a review and there is no abstract. The objectives are as follows:
To determine which treatment regimen (that must include one or more of chemotherapy, radiotherapy or biotherapy) given with the intention to cure HPV-positive local advanced oropharyngeal squamous cell cancer will lead to the best outcomes in terms of overall survival, treatment-related morbidity and side effects. Comparison will be drawn between treatment regimens that have different therapeutic agents, dosing or delivery methods.
To determine the implications of treatment modalities in terms of quality of life, disease-free survival and costs.