Mycophenolate mofetil versus methotrexate for prevention of acute graft-versus-host disease in patients receiving allogeneic hematopoietic stem cell transplantation

  • Protocol
  • Intervention

Authors

  • Mohamed Kharfan-Dabaja,

    1. Division of Oncologic Sciences, University of South Florida, Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, Florida, USA
    2. American University of Beirut, Division of Hematology-Oncology and Bone Marrow Transplantation Program, Beirut, Lebanon
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  • Rahul Mhaskar,

    1. University of South Florida, Center for Evidence Based Medicine and Health Outcomes Research, Tampa, Florida, USA
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  • Tea Reljic,

    1. University of South Florida, Center for Evidence Based Medicine and Health Outcomes Research, Tampa, Florida, USA
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  • Joseph Pidala,

    1. Division of Oncologic Sciences, University of South Florida, Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, Florida, USA
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  • Janelle B Perkins,

    1. Division of Oncologic Sciences, University of South Florida, Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, Florida, USA
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  • Benjamin Djulbegovic,

    1. Division of Oncologic Sciences, University of South Florida, Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, Tampa, Florida, USA
    2. USF Health Clinical Research, University of South Florida, USF Clinical Translational Science Institute, Dpts of Medicine, Hematology and Health Outcome Research, USF and H. Lee Moffitt Cancer Center, Tampa, Florida, USA
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  • Ambuj Kumar

    Corresponding author
    1. University of South Florida, Center for Evidence Based Medicine and Health Outcomes Research, Tampa, Florida, USA
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The primary objective of this review is to assess the effect of mycophenolate mofetil versus methotrexate for the prevention of acute GVHD in patients undergoing allo-HCT.

Our secondary objectives are to evaluate the effect of methotrexate versus mycophenolate mofetil in terms of the prevention of chronic GVHD, relapse rate, treatment-related harms, and non-relapse mortality.