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Inhaled anticholinergics and short-acting beta2-agonists versus short-acting beta2-agonists alone for children with acute asthma in hospital

  1. Kevin Vézina1,
  2. Bhupendrasinh F Chauhan2,
  3. Francine M Ducharme3,4,*

Editorial Group: Cochrane Airways Group

Published Online: 31 JUL 2014

Assessed as up-to-date: 17 DEC 2013

DOI: 10.1002/14651858.CD010283.pub2


How to Cite

Vézina K, Chauhan BF, Ducharme FM. Inhaled anticholinergics and short-acting beta2-agonists versus short-acting beta2-agonists alone for children with acute asthma in hospital. Cochrane Database of Systematic Reviews 2014, Issue 7. Art. No.: CD010283. DOI: 10.1002/14651858.CD010283.pub2.

Author Information

  1. 1

    CHU Sainte-Justine, Department of Pediatrics, Montreal, QC, Canada

  2. 2

    Research Centre, CHU Sainte-Justine, Clinical Research Unit on Childhood Asthma, Montreal, QC, Canada

  3. 3

    University of Montreal, Department of Paediatrics, Montreal, QC, Canada

  4. 4

    CHU Sainte-Justine, Research Centre, Montreal, Canada

*Francine M Ducharme, Department of Paediatrics, University of Montreal, Montreal, QC, Canada. francine.m.ducharme@umontreal.ca.

Publication History

  1. Publication Status: New
  2. Published Online: 31 JUL 2014

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Forest plot: Combination of anticholinergics + β2-agonists versus β2-agonists alone, outcome: duration of the hospital stay (hours).
[Analysis 1.1]
Analysis 1.1. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 1 Duration of hospital stay (hours).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 2 Admission to the intensive care unit.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 3 Need for supplemental asthma therapy.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 4 Time to short-acting β2-agonists spaced at 4 hours or longer (hours).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 5 Asthma clinical scores 8 to 36 hours after initial treatment.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 6 Relapse within 72 hours of discharge from hospital.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 7 Percentages of predicted PEFR at 8 to 36 hours after initial treatment.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 8 Adverse health effects.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 9 Overall withdrawals.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Combination of anticholinergics (AC) + β2-agonists versus β2-agonists alone, Outcome 10 Withdrawals due to deterioration.