Intervention Protocol

Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas in patients with previous adenomas and/or genetic disposition

  1. Andrew R Latchford1,
  2. Yasuko Maeda2,*,
  3. Susan K Clark3

Editorial Group: Cochrane Colorectal Cancer Group

Published Online: 31 JAN 2013

Assessed as up-to-date: 19 NOV 2012

DOI: 10.1002/14651858.CD010291

How to Cite

Latchford AR, Maeda Y, Clark SK. Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas in patients with previous adenomas and/or genetic disposition (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD010291. DOI: 10.1002/14651858.CD010291.

Author Information

  1. 1

    St Mark´s Hospital, Polyposis Registry, Harrow, UK

  2. 2

    St Mark's Hospital, Sir Alan Park's Physiology Unit, Harrow, UK

  3. 3

    St Mark´s Hospital, Polyposis Registry and Department of Surgery, Harrow, UK

*Yasuko Maeda, Sir Alan Park's Physiology Unit, St Mark's Hospital, Northwick Park, Watford Road, Harrow, UK. yazmaeda@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 31 JAN 2013

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine if administration of nonsteroidal anti-inflammatory drugs (NSAID) and/or aspirin is effective as chemoprevention for colorectal adenomas and carcinomas in patients with previous colorectal adenomas and/or those who have genetic predispositions, compared to currently available other agents or no intervention and to assess adverse effects associated with the intervention.

 

The following hypotheses will be tested:

1. NSAID and/or aspirin is better than no intervention

2. NSAID and/or aspirin is better than a placebo/sham intervention;

3. Aspirin with combination of resistant starch is better than no intervention;

4. One type of NSAID is better than another type;

5. Increased dose of NSAID and/or aspirin is better than another dose.