Intervention Protocol

Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing recurrence and metachronous colorectal carcinomas in patients previously treated for colorectal cancer

  1. Andrew R Latchford1,
  2. Yasuko Maeda2,*,
  3. Susan K Clark3

Editorial Group: Cochrane Colorectal Cancer Group

Published Online: 31 JAN 2013

Assessed as up-to-date: 1 AUG 2012

DOI: 10.1002/14651858.CD010325


How to Cite

Latchford AR, Maeda Y, Clark SK. Nonsteroidal anti-inflammatory drugs (NSAID) and aspirin for preventing recurrence and metachronous colorectal carcinomas in patients previously treated for colorectal cancer (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD010325. DOI: 10.1002/14651858.CD010325.

Author Information

  1. 1

    St Mark´s Hospital, Polyposis Registry, Harrow, UK

  2. 2

    St Mark's Hospital, Sir Alan Park's Physiology Unit, Harrow, UK

  3. 3

    St Mark´s Hospital, Polyposis Registry and Department of Surgery, Harrow, UK

*Yasuko Maeda, Sir Alan Park's Physiology Unit, St Mark's Hospital, Northwick Park, Watford Road, Harrow, UK. yazmaeda@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 31 JAN 2013

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine if administration of nonsteroidal anti-inflammatory drugs (NSAID) and/or aspirin is effective as chemoprevention for colorectal cancer in patients with previous colorectal carcinomas, compared to currently available other agents or no intervention and to assess adverse effects associated with the intervention.

The following hypotheses will be tested:

1. NSAID and/or aspirin is better than no intervention

2. NSAID and/or aspirin is better than a placebo/sham intervention;

3. Aspirin with combination of resistant starch is better than no intervention;

4. One type of NSAID is better than another type;

5. Increased dose of NSAID and/or aspirin is better than another dose.