Intervention Protocol

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Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients

  1. Dimitrios Kloukos1,*,
  2. Piotr Fudalej1,2,
  3. Patrick Sequeira-Byron3,
  4. Christos Katsaros1

Editorial Group: Cochrane Oral Health Group

Published Online: 28 FEB 2013

DOI: 10.1002/14651858.CD010403

How to Cite

Kloukos D, Fudalej P, Sequeira-Byron P, Katsaros C. Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD010403. DOI: 10.1002/14651858.CD010403.

Author Information

  1. 1

    University of Bern, Department of Orthodontics and Dentofacial Orthopedics, Bern, Switzerland

  2. 2

    Palacky University Olomouc, Orthodontics, Olomouc, Czech Republic

  3. 3

    University of Bern, Department of Preventive, Restorative and Pediatric Dentistry, Bern, Bern, Switzerland

*Dimitrios Kloukos, Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Freiburgstrasse 7, Bern, 3010, Switzerland.

Publication History

  1. Publication Status: New
  2. Published Online: 28 FEB 2013



Additional references

Chung 2000
  • Chung KC, Kowalski CP, Kim HM, Buchman SR. Maternal cigarette smoking during pregnancy and the risk of having a child with cleft lip/palate. Plastic and Reconstructive Surgery 2000;105(2):485-91.
Czeizel 1997
Egger 1997
  • Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315(7109):629-34.
Hayes 2002
  • Hayes C. Environmental risk factors and oral clefts. In: Wyszynski DF editor(s). Cleft Lip and Palate. From Origin to Treatment. New York: Oxford University Press, 2002:159-69.
Hecht 1989
Hecht 1990
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Iannetti 2004
Ilizarov 1989
  • Ilizarov GA. The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation. Clinical Orthopaedics and Related Research 1989;(238):249-81.
McCarthy 1992
McCarthy 2001
Mossey 2007
Mølsted 2005
  • Mølsted K, Brattström V, Prahl-Andersen B, Shaw WC, Semb G. The Eurocleft study: intercenter study of treatment outcome in patients with complete cleft lip and palate. Part 3: dental arch relationships. The Cleft Palate-Craniofacial Journal 2005;42(1):78-82.
Oberoi 2005
Phillips 2012
  • Phillips JH, Nish I, Daskalogiannakis J. Orthognathic surgery in cleft patients. Plastic and Reconstructive Surgery 2012;129(3):535e-548e.
Romitti 1999
  • Romitti PA, Lidral AC, Munger RG, Daack-Hirsch S, Burns TL, Murray JC. Candidate genes for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts. Teratology 1999;59(1):39-50.
Romitti 2007
  • Romitti PA, Sun L, Honein MA, Reefhuis J, Correa A, Rasmussen SA. Maternal periconceptional alcohol consumption and risk of orofacial clefts. American Journal of Epidemiology 2007;166(7):775-85.
Saltaji 2012a
  • Saltaji H, Major MP, Alfakir H, Al-Saleh MA, Flores-Mir C. Maxillary advancement with conventional orthognathic surgery in patients with cleft lip and palate: is it a stable technique?. Journal of Oral and Maxillofacial Surgery 2012;70(12):2859-66.
Saltaji 2012b
  • Saltaji H, Major MP, Altalibi M, Youssef M, Flores-Mir C. Long-term skeletal stability after maxillary advancement with distraction osteogenesis in cleft lip and palate patients. The Angle Orthodontist 2012;82(6):1115-22.
Scolozzi 2008
Shaw 1995
  • Shaw GM, Lammer EJ, Wasserman CR, O'Malley CD, Tolarova MM. Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet 1995;346(8972):393-6.
Shaw 1999
Shaw 2001
Shaw 2002
WHO 2012
  • World Health Organization. Oral health. Fact sheet N° 318 April 2012. Available from
Wong 1999