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Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with abdominal aortic aneurysm

  1. Lindsay Robertson1,*,
  2. Edmond Atallah2,
  3. Gerard Stansby3

Editorial Group: Cochrane Vascular Group

Published Online: 21 JAN 2014

Assessed as up-to-date: 10 APR 2013

DOI: 10.1002/14651858.CD010447.pub2


How to Cite

Robertson L, Atallah E, Stansby G. Pharmacological treatment of vascular risk factors for reducing mortality and cardiovascular events in patients with abdominal aortic aneurysm. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD010447. DOI: 10.1002/14651858.CD010447.pub2.

Author Information

  1. 1

    Freeman Hospital, Department of Vascular Surgery, Newcastle upon Tyne, UK

  2. 2

    Mid Cheshire Hospitals NHS Foundation Trust, Leighton Hospital, Crewe, Cheshire, UK

  3. 3

    Freeman Hospital, Northern Vascular Centre, Newcastle upon Tyne, UK

*Lindsay Robertson, Department of Vascular Surgery, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. lindsay.robertson@nuth.nhs.uk. lindsay.robertson@ed.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 21 JAN 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Yang 2006 {published data only}
  • Yang H, Raymer K, Butler R, Parlow J, Roberts R. The effects of perioperative β-blockade: Results of the metoprolol after vascular surgery (MaVS) study, a randomized controlled trial. American Heart Journal 2006;152(5):983-90.
  • Yang H, Raymer K, Butler R, Parlow J, Roberts R, Tech M. Metoprolol after vascular surgery. Canadian Journal of Anaesthesia 2004;51 Suppl 1:A7.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Cesanek 2008 {published data only}
  • Cesanek P, Schwann N, Wilson E, Urffer S, Maksimik C, Nabhan S, et al. The effect of beta-blocker dosing strategy on regulation of perioperative heart rate and clinical outcomes in patients undergoing vascular surgery: A randomized comparison. Annals of Vascular Surgery 2008;22(5):643-8.
DECREASE Study {published data only}
  • Bakker EJ, Ravensbergen NJ, Voute MT, Hoeks SE, Chonchol M, Klimek M, et al. A randomised study of perioperative esmolol infusion for haemodynamic stability during major vascular surgery: Rationale and design of DECREASE-XIII. European Journal of Vascular and Endovascular Surgery 2011;42(3):317-23.
  • Dunkelgrun M, Boersma E, Koopman-Van Gemert AWMM, Van Poorten F, Kalkman C, Schouten O, et al. Fluvastatin and bisoprolol for cardiac risk reduction in intermediate-risk patients undergoing non-cardiovascular surgery: a randomised controlled trial. European Heart Journal 2008;29(Abstract Suppl):602-3.
  • Dunkelgrun M, Boersma E, Schouten O. Koopman-Van Gemert AWMM, Van Poorten F, Bax JJ, et al. for The Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. Bisoprolol and fluvastatin for the reduction of perioperative cardiac mortality and myocardial infarction in intermediate-risk patients undergoing noncardiovascular surgery: a randomised controlled trial (DECREASE-IV). Annals of Surgery 2009;249(6):921-6.
  • Flu WJ, van Kujik JP, Conchol M, Winkel TA, Verhagen HJ, Bax JJ, et al. Timing of perioperative Beta-blocker treatment in vascular surgery patients: influence on post-operative outcome. Journal of the American College of Cardiology 2010;56(23):1922-9.
  • Hoeks SE, Schouten O, Dunkelgrun M, Van Lier F, Durazzo AE, Neskovich AN, et al. Perioperative stroke in non-cardiac surgery; the impact of prophylactic beta-blocker therapy. European Heart Journal 2008;29(Abstract Supplement):395.
  • Poldermans D, Bax JJ, Schouten O, Neskovic AN, Paelinck B, Rocci G, et al. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echo Study Group. Should major vascular surgery be delayed because of preoperative cardiac testing in intermediate-risk patients receiving beta-blocker therapy with tight heart rate control?. Journal of the American College of Cardiology 2006;48(5):964-9.
  • Poldermans D, Boersma E, Bax JJ, Leendertse-Verloop K, Poldermans VC, Yo TI, et al. With bisoprolol fewer perioperative cardiac complications in high-risk patients undergoing major vascular surgery. Nederlands Tijdschrift voor Geneeskunde 2000;144(42):2011-4.
  • Poldermans D, Boersma E, Bax JJ, Thomson IR, Paelinck B, Van de Ven LL, et al. Bisprolol reduces cardiac death and myocardial infarction in high-risk patients as long as 2 years after successful major vascular surgery. European Heart Journal 2001;22(15):1353-8.
  • Poldermans D, Boersma E, Bax JJ, Thomson IR, van de Ven LL, Blankensteijn JD, et al. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. New England Journal of Medicine 1999;341(24):1789-94.
  • Poldermans D, Shelton M. Fluvastatin XL use is associated with improved cardiac outcome after major vascular surgery. Results from a randomised placebo controlled trial: DECREASE III. European Society of Cardiology Congress. 2008.
  • Schouten O, Boersma E, Hoeks SE, Benner R, van Urk H, Van Sambeek MR, et al. for the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. Fluvastatin and perioperative events in patients undergoing vascular surgery. New England Journal of Medicine 2009;361(10):980-9.
  • Schouten O, Hoeks SE, Voute MT, Boersma E, Verhagen HJ, Poldermans D. Long-term benefit of perioperative statin use in patients undergoing vascular surgery: Results from the DECREASE III trial. Journal of Vascular Surgery 2011;53(6):20S-1S.
  • Schouten O, Poldermans D, Visser L, Kertai MD, Klein J, van Urk H, et al. Fluvastatin and bisoprolol for the reduction of perioperative cardiac mortality and morbidity in high-risk patients undergoing non-cardiac surgery: rationale and design of the DECREASE-IX study. American Heart Journal 2004;148(6):1047-52.
Durazzo 2004 {published data only}
  • Caramelli B, Durazzo A, Ikeoka D, De Bernoche C, Monachini M, Puech LP, et al. Short-term treatment with atorvastatin for prevention of cardiac complications after vascular surgery. Abstract No 086. Atherosclerosis Supplements 2002;3:83.
  • Durazzo AE, Machado FS, Ikeoka D, Puech LP, Caramelli B. Effect of atorvastatin on cardiovascular events after vascular surgery. Circulation 2002;106(II):343.
  • Durazzo AE, Machado FS, Ikeoka DT, De Bernoche C, Monachini MC, Puech-Leao P, et al. Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomised trial. Journal of Vascular Surgery 2004;39(5):967-75.
Kouvelos 2013 {published data only}
  • Kouvelos GN, Arnaoutoglou EM, Matsagkas MI, Kostara C, Gartzonika C, Bairaktari ET, et al. Effects of rosuvastatin with or without ezetimibe on clinical outcomes in patients undergoing elective vascular surgery: Results of a pilot study. Journal of Cardiovascular Pharmacology and Therapeutics 2013;18(1):5-12.
Mackey 2006 {published data only}
  • Mackey WC, Fleisher La, Haider S, Sheikh S, Cappalleri JC, Lee WC, et al. Perioperative myocardial ischemic injury in high-risk vascular surgery patients: incidence and clinical significance in a prospective clinical trial. Journal of Vascular Surgery 2006;43(3):533-8.
Mangano 1996 {published data only}
  • Mangano DT, Layug EL, Wallace A, Tateo I, for the Multicentre Study of Perioperative Ischemia Research Group. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. New England Journal of Medicine 1996;335(23):1713-21.
Neilipovitz 2012 {published data only}
  • Neilipovitz DT, Bryson GL, Taljaard M. STAR VaS--Short term atorvastatin regime for vasculopathic subjects: a randomized placebo-controlled trial evaluating perioperative atorvastatin therapy in noncardiac surgery. Canadian Journal of Anaesthesia 2012;59(6):527-37.
POBBLE Trial {published data only}
  • Brady AR, Gibbs JS, Greenhalgh RM, Powell JT, Sydes MR, POBBLE trial investigators. Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial. Journal of Vascular Surgery 2005;41(4):602-9.
  • Schouten O, van Urk H, Feringa HH, Bax JJ, Poldermans D. Regarding "Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial" [comment]. Journal of Vascular Surgery 2005;42(4):825, author reply 826.
POISE Study {published data only}
  • Devereaux PJ . The perioperative ischemic evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. Clinical Research in Cardiology 2008;97(1):8.
  • POISE Trial Investigators: Devereaux PJ, Yang H, Guyatt GH, Leslie K, Villar JC, Monteri VM, et al. Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. American Heart Journal 2006;152(2):223-30.
  • POISE study group, Devereaux PJ, Yang H, Yusuf S, Guyatt G, Leslie K, Villar JC, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 2008;371(9627):1839-47.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Badger 2009
  • Badger SA, O'Donnell ME, Sharif MA, McMaster C, Young IS, Soong CV. The role of smoking in abdominal aortic aneurysm development. Angiology 2009;60(1):115-9.
Blanchard 2000
Bolsin 2013
  • Bolsin S, Colson M, Marsiglio A. Perioperative ß-blockade. For patients undergoing non-cardiac surgery, only those needing heart rate or blood pressure control perioperatively should start blockers. BMJ 2013;347:f5640.
Brown 1999
Brown 2011
  • Brown LC,  Thompson SG,  Greenhalgh RM,  Powell JT,  Endovascular Aneurysm Repair trial participants. Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1. British Journal of Surgery 2011;98(7):935-42.
Davis 2008
de Bruin 2013
  • de Bruin JL, Baas AF, Heymans MW, Buimer MG, Prinssen M, Grobbee DE, et al. Statin therapy is associated with improved survival after endovascular and open aneurysm repair. Journal of Vascular Surgery 2013;pii: S0741-5214(13):01338-4.
De Martino 2013
  • De Martino RR, Goodney PP, Nolan BW, Robinson WP, Farber A, Patel VI, et al. Optimal selection of patients for elective abdominal aortic aneurysm repair based on life expectancy. Journal of Vascular Surgery 2013;58(3):589-95.
Deeks 2011
  • Deeks JJ, Higgins JPT, Altman DG (editors). Chapter 9: Analysing data and undertaking meta-analyses. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Dillon 2007
Filardo 2012
Greenhalgh 2004
  • Greenhalgh RM, Brown LC, Kwong GP,  Powell JT, Thompson SG, EVAR trial participants. Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: randomised controlled trial. Lancet 2004;364(9437):843-8.
Greenhalgh 2008
Hackam 2006
Higgins 2011
  • Higgins JPT, Altman DG, Sterne JAC (editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hirsch 2005
  • Hirsch AT, Haskal ZJ, Hertzer NR, Bakal CW, Creager MA, Halperin JL, et al. ACC/AHA 2005 Practice Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): a collaborative report from the American Association for Vascular Surgery/Society for Vascular Surgery, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and ACC/AHA Task Force on Practice Guidelines: endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation; National Heart, Lung, and Blood Institute; Society for Vascular Nursing; TransAtlantic Inter-Society Consensus; and Vascular Disease Foundation. Circulation 2006;113(11):e463-e654.
Kertai 2004
  • Kertai MD, Boersma E, Westerhout CM, van Domburg R, Klein J, Bax JJ, et al. Association between long-term statin use and mortality after successful abdominal aortic aneurysm surgery. American Journal of Medicine 2004;116(2):96-103.
Lloyd 2010
  • Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. on behalf of the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation 2010;121(7):e46-e215.
Morange 2006
  • Morange PE, Bickel C, Nicaud V, Schnabel R, Rupprecht HJ, Peetz D, et al. AtheroGene Investigators. Haemostatic factors and the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study. Arteriosclerosis, Thrombosis, and Vascular Biology 2006;26(12):2793-9.
Ohrlander 2011
  • Ohrlander T, Dencker M, Dias NV, Gottsäter A, Acosta S. Cardiovascular predictors for long-term mortality after EVAR for AAA. Vascular Medicine 2011;16:422-7.
Parr 2011
  • Parr A, McCann M, Bradshaw B, Shahzad A, Buttner P, Golledge J. Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms. Journal of Vascular Surgery 2011;53(1):28-35.
Parry 2009
Pleumeekers 1995
  • Pleumeekers HJCM, Hoes AW, Van Der Does E, van Urk H, Hofman A, de Jong PTVM, et al. Aneurysms of the abdominal aorta in older adults. The Rotterdam Study. American Journal of Epidemiology 1995;142(12):1291–9 .
Prinssen 2004
  • Prinssen M, Verhoeven ELG, Buth J, Cuypers PWM, van Sambeek MR, Balm R, et al. for the Dutch Randomized Endovascular Aneurysm Management (DREAM) Trial Group. A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms. New England Journal of Medicine 2004;351(16):1607-18.
Rughani 2012
Schouten 2006
  • Schouten O,  Kok NF,  Hoedt MT,  van Laanen JH,  Poldermans D. The influence of aneurysm size on perioperative cardiac outcome in elective open infrarenal aortic aneurysm repair. Journal of Vascular Surgery 2006;44(3):435-41.
Scott 2002
Singh 2001
  • Singh K, Bonaa KH, Jacobsen BK, Bjork L, Solberg S. Prevalence of and risk factors for abdominal aortic aneurysms in a population-based study. The Tromso Study. American Journal of Epidemiology 2001;154(3):236-44.
Smith 2005
  • Smith A, Patterson C, Yarnell J, Rumley A, Ben-Schlomo Y, Lowe G. Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly study. Circulation 2005;112(20):3080-7.
Sterne 2011
  • Sterne JAC, Egger M, Moher D (editors). Chapter 10: Addressing reporting biases. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Takagi 2009
  • Takagi H, Manabe H, Kawai N, Goto S, Umemoto T. Plasma fibrinogen and D-dimer concentrations are associated with the presence of abdominal aortic aneurysm: a systematic review and meta-analysis. European Journal of Vascular and Endovascular Surgery 2009;38(3):273-7.
Timmers 2013
  • Timmers TK, van Herwaarden JA, de Borst GJ, Moll FL, Leenen LP. Long-term survival and quality of life after open abdominal aortic aneurysm repair. World Journal of Surgery 2013;37(12):2957-6.
van Vlijmen-van Keulen 2002
  • van Vlijmen-van Keulen CJ, Pals G, Rauwerda JA. Familial abdominal aortic aneurysm: a systematic review of a genetic background. European Journal of Vascular and Endovascular Surgery 2002;24(2):105-16.
Wanhainen 2008
  • Wanhainen A. How to define an abdominal aortic aneurysm--influence on epidemiology and clinical practice. Scandinavian Journal of Surgery 2008;97(2):105-9, discussion 109.
Wilmink 1999