Intervention Protocol

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Treatment of enteric fever (typhoid and paratyphoid fever) with third and fourth generation cephalosporins

  1. Nicole Stoesser1,*,
  2. David Eyre2,
  3. Buddha Basnyat3,
  4. Christopher Parry4

Editorial Group: Cochrane Infectious Diseases Group

Published Online: 28 MAR 2013

DOI: 10.1002/14651858.CD010452


How to Cite

Stoesser N, Eyre D, Basnyat B, Parry C. Treatment of enteric fever (typhoid and paratyphoid fever) with third and fourth generation cephalosporins (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD010452. DOI: 10.1002/14651858.CD010452.

Author Information

  1. 1

    University of Oxford & Cambodia-Oxford-Mahidol Research Programme, Department of Microbiology (Research), Oxford, UK

  2. 2

    John Radcliffe Hospital, Department of Microbiology (Research), Oxford, UK

  3. 3

    Nepal International Clinic, Oxford Clinical Research Unit/Patan Academy of Health Science, Kathmandu, Nepal

  4. 4

    Hospital for Tropical Diseases, Oxford Clinical Research Unit (OUCRU), Ho Chi Minh City, Viet Nam

*Nicole Stoesser, Department of Microbiology (Research), University of Oxford & Cambodia-Oxford-Mahidol Research Programme, Level 7, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK. nicole.stoesser@ndm.ox.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 28 MAR 2013

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To evaluate third and fourth generation cephalosporins in the treatment of enteric fever in children and adults compared with other antibiotics. The primary objectives are:

  • to identify whether the drugs under scrutiny are clinically effective
  • which is the optimal agent and at what dose
  • what is the most appropriate route of administration
  • what is the ideal treatment duration

Therefore, we will perform within-class comparisons and an assessment of third and fourth generation cephalosporin treatment duration.