Transient elastography for diagnosis of hepatic fibrosis in people with alcoholic liver disease

  • Protocol
  • Diagnostic

Authors

  • Chavdar S Pavlov,

    Corresponding author
    1. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, The Cochrane Hepato-Biliary Group, Copenhagen, Denmark
    2. I.M. Sechenov First Moscow State Medical University, Clinic of Internal Diseases Propedeutics, Moscow, Russian Federation
    • Chavdar S Pavlov, The Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, DK-2100, Denmark. chpavlov@mail.ru.

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  • Giovanni Casazza,

    1. University of Milan, Dipartimento di Scienze Biomediche e Cliniche "L. Sacco", Milan, Italy
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  • Dimitrinka Nikolova,

    1. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, The Cochrane Hepato-Biliary Group, Copenhagen, Denmark
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  • Vladimir T Ivashkin,

    1. I.M. Sechenov First Moscow State Medical University, Clinic of Internal Diseases Propedeutics, Moscow, Russian Federation
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  • Christian Gluud

    1. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 7812, Rigshospitalet, Copenhagen University Hospital, The Cochrane Hepato-Biliary Group, Copenhagen, Denmark
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Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

To determine the diagnostic accuracy of transient elastography for detecting hepatic fibrosis in people with alcoholic liver disease when compared with liver biopsy as reference standard. In particular, no significant hepatic fibrosis (F0, F1) and significant hepatic fibrosis (F2, F3, F4), no cirrhosis (F0, F1, F2, F3) and cirrhosis (F4).