Intervention Protocol

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Banding ligation versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children

  1. Juan Cristóbal Gana1,*,
  2. Lorena I Cifuentes2,
  3. Jaime Cerda3,
  4. Luis A Villarroel del Pino3,
  5. Alfredo Peña4,
  6. Marcela Rivera Cornejo5

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 31 MAY 2013

Assessed as up-to-date: 31 OCT 2012

DOI: 10.1002/14651858.CD010546


How to Cite

Gana JC, Cifuentes LI, Cerda J, Villarroel del Pino LA, Peña A, Rivera Cornejo M. Banding ligation versus beta-blockers for primary prophylaxis of oesophageal variceal bleeding in children (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 5. Art. No.: CD010546. DOI: 10.1002/14651858.CD010546.

Author Information

  1. 1

    Division of Paediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Gastroenterology, Hepatology, and Nutrition Unit, Santiago, Region Metropolitana, Chile

  2. 2

    Escuela de Medicina, Pontificia Universidad Católica de Chile, Division of Paediatrics, Evidence-based Health Care Programme, Santiago, Metroplitana, Chile

  3. 3

    Faculty of Medicine, Pontificia Universidad Católica de Chile, Department of Public Health, Santiago, Chile

  4. 4

    Escuela de Medicina, Pontificia Universidad Católica de Chile, Department of Paediatrics, Division of Paediatrics, Santiago, Chile

  5. 5

    Pontificia Universidad Católica de Chile, Biblioteca Biomedica, Sistema de Bibliotecas, Santiago, Región Metropolitana, Chile

*Juan Cristóbal Gana, Gastroenterology, Hepatology, and Nutrition Unit, Division of Paediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, 85 Lira, Santiago, Region Metropolitana, 8330074, Chile. jcgana@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 31 MAY 2013

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References

Additional references

Bambha 2008
  • Bambha K, Kim WR, Pedersen R, Bida JP, Kremers WK, Kamath PS. Predictors of early re-bleeding and mortality after acute variceal haemorrhage in patients with cirrhosis. Gut 2008;57(6):814-20. [PUBMED: 18250126]
Bellentani 1994
Brok 2008
  • Brok J, Thorlund K, Gluud C, Wetterslev J. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. Journal of Clinical Epidemiology 2008;61:763-9.
Brok 2009
  • Brok J, Thorlund K, Wetterslev J, Gluud C. Apparently conclusive meta-analyses may be inconclusive - Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. International Journal of Epidemiology 2009;38(1):287-98.
CTU 2011
  • Copenhagen Trial Unit. TSA - Trial Sequential Analysis. http://ctu.dk/tsa/ 2011 (accessed 12 April 2013).
D'Amico 1995
D'Amico 2003
D'Amico 2006
  • D'Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. Journal of Hepatology 2006;44(1):217-31. [PUBMED: 16298014]
Duche 2010
  • Duche M, Ducot B, Tournay E, Fabre M, Cohen J, Jacquemin E, et al. Prognostic value of endoscopy in children with biliary atresia at risk for early development of varices and bleeding. Gastroenterology 2010;139(6):1952-60. [PUBMED: 20637201]
Eroglu 2004
  • Eroglu Y, Emerick KM, Whitingon PF, Alonso EM. Octreotide therapy for control of acute gastrointestinal bleeding in children. Journal of Pediatric Gastroenterology and Nutrition 2004;38(1):41-7. [PUBMED: 14676593]
Gana 2011
  • Gana JC, Valentino PL, Morinville V, O'Connor C, Ling SC. Variation in care for children with esophageal varices: a study of physicians', patients', and families' approaches and attitudes. Journal of Pediatric Gastroenterology and Nutrition 2011;52(6):751-5. [PUBMED: 21593647]
Gana 2013a
  • Gana JC. Banding ligation versus placebo or no intervention for primary prophylaxis of esophageal varices in children. Cochrane Database of Systematic Reviews 2013 (Under preparation).
Gana 2013b
  • Gana JC. Banding ligation versus sclerotheraphy for primary prophylaxis of esophageal varices in children. Cochrane Database of Systematic Reviews 2013 (Under preparation).
Gana 2013c
  • Gana JC. Beta-blockers versus placebo or no intervention for primary prophylaxis of esophageal varices in children. Cochrane Database of Systematic Reviews 2013 (Under preparation).
Gana 2013d
  • Gana JC. Sclerotheraphy versus beta-blockers for primary prophylaxis of esophageal varices in children. Cochrane Database of Systematic Reviews 2013 (Under preparation).
Gana 2013e
  • Gana JC. Sclerotheraphy versus placebo or no intervention for primary prophylaxis of esophageal varices in children. Cochrane Database of Systematic Reviews 2013 (Under preparation).
Garceau 1963
Garcia-Tsao 2007
  • Garcia-Tsao G, Sanyal AJ, Grace ND, Carey WD. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. The American Journal of Gastroenterology 2007;102(9):2086-102. [PUBMED: 17727436]
    Direct Link:
Garcia-Tsao 2008
  • Garcia-Tsao G, Bosch J, Groszmann RJ. Portal hypertension and variceal bleeding - unresolved issues. Summary of an American Association for the Study of Liver Diseases and European Association for the Study of the Liver single-topic conference. Hepatology 2008; Vol. 47, issue 5:1764-72. [PUBMED: 18435460]
Gluud 2013
  • Gluud C, Nikolova D, Klingenberg SL, Alexakis N, Als-Nielsen B, Colli A, et al. Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)). 2013, Issue 3. Art. No.: LIVER.
Goncalves 2000
  • Goncalves ME, Cardoso SR, Maksoud JG. Prophylactic sclerotherapy in children with esophageal varices: long-term results of a controlled prospective randomized trial. Journal of Pediatric Surgery 2000;35(3):401-5. [PUBMED: 10726678]
Graham 1981
Hayes 1990
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Imperiale 2001
Jensen 2002
Kamath 2001
Kjaergard 2001
Kobayashi 1984
  • Kobayashi A, Itabashi F, Ohbe Y. Long-term prognosis in biliary atresia after hepatic portoenterostomy: analysis of 35 patients who survived beyond 5 years of age. The Journal of Pediatrics 1984;105(2):243-6. [PUBMED: 6611395]
Lebrec 1980
  • Lebrec D, De Fleury P, Rueff B, Nahum H, Benhamou JP. Portal hypertension, size of esophageal varices, and risk of gastrointestinal bleeding in alcoholic cirrhosis. Gastroenterology 1980;79(6):1139-44. [PUBMED: 6969201]
Lundh 2012
Lykavieris 2000
  • Lykavieris P, Gauthier F, Hadchouel P, Duche M, Bernard O. Risk of gastrointestinal bleeding during adolescence and early adulthood in children with portal vein obstruction. The Journal of Pediatrics 2000;136(6):805-8. [PUBMED: 10839880]
McDiarmid 2002
  • McDiarmid SV, Anand R, Lindblad AS. Development of a pediatric end-stage liver disease score to predict poor outcome in children awaiting liver transplantation. Transplantation 2002;74(2):173-81. [PUBMED: 12151728]
Merli 2003
  • Merli M, Nicolini G, Angeloni S, Rinaldi V, De Santis A, Merkel C, et al. Incidence and natural history of small esophageal varices in cirrhotic patients. Journal of Hepatology 2003;38(3):266-72. [PUBMED: 12586291]
Miga 2001
  • Miga D, Sokol RJ, Mackenzie T, Narkewicz MR, Smith D, Karrer FM. Survival after first esophageal variceal hemorrhage in patients with biliary atresia. The Journal of Pediatrics 2001;139(2):291-6. [PUBMED: 11487759]
Mitra 1978
Moher 1998
  • Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. Lancet 1998;352(9128):609-13.
NIEC 1988
  • North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. The New England Journal of Medicine 1988;319(15):983-9. [PUBMED: 3262200]
Pugh 1973
Quinn 1997
  • Quinn PG, Johnston DE. Detection of chronic liver disease: costs and benefits. The Gastroenterologist 1997;5(1):58-77. [PUBMED: 9074920]
RDCT 2012 [Computer program]
  • R Development Core Team. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing (http://www.R-project.org/), 2012 (accessed 24 April 2013).
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Royle 2003
  • Royle P, Milne R. Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches. International Journal of Technology Assessment in Health Care 2003;19(4):591-603.
Savovic 2012
  • Savovic J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Health Technology Assessment 2012;16(35):1-82.
Savovic 2012a
  • Savovic J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Annals of Internal Medicine 2012;157(6):429-38.
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12.
Sharara 2001
Shneider 2004
  • Groszmann RJ, Bosch J. Portal hypertension in the 21st century. Dordrecht, The Netherlands: Kluwer Academic Publishers, 2004.
Stringer 1989
  • Stringer MD, Howard ER, Mowat AP. Endoscopic sclerotherapy in the management of esophageal varices in 61 children with biliary atresia. Journal of Pediatric Surgery 1989;24(5):438-42. [PUBMED: 2786958]
Thorlund 2009
  • Thorlund K, Devereaux PJ, Wetterslev J, Guyatt G, Ioannidis JP, Thabane L, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses. International Journal of Epidemiology 2009;38(1):276-86.
Thorlund 2010
  • Thorlund K, Anema A, Mills E. Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals. Clinical Epidemiology 2010;2:57-66.
Thorlund 2011
  • Thorlund K, Engstrøm J, Wetterslev J, Brok J, Imberger G, Gluud C. User manual forTrial Sequential Analysis (TSA). http://ctu.dk/tsa/files/tsa_manual.pdf 2011 (accessed 24 April 2013).
Thorlund 2011a
  • Thorlund K, Imberger G, Walsh M, Chu R, Gluud C, Wetterslev J, et al. The number of patients and events required to limit the risk of overestimation of intervention effects in meta-analysis - a simulation study. PLoS One 2011;6(10):e25491.
Toyosaka 1993
  • Toyosaka A, Okamoto E, Okasora T, Nose K, Tomimoto Y. Outcome of 21 patients with biliary atresia living more than 10 years. Journal of Pediatric Surgery 1993;28(11):1498-501. [PUBMED: 8301468]
van Heurn 2004
  • van Heurn LW, Saing H, Tam PK. Portoenterostomy for biliary atresia: Long-term survival and prognosis after esophageal variceal bleeding. Journal of Pediatric Surgery 2004;39(1):6-9. [PUBMED: 14694362]
Webb 1979
  • Webb LJ, Sherlock S. The aetiology, presentation and natural history of extra-hepatic portal venous obstruction. The Quarterly Journal of Medicine 1979;48(192):627-39. [PUBMED: 538223]
Wetterslev 2008
  • Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. Journal of Clinical Epidemiology 2008;61(1):64-75.
Wetterslev 2009
  • Wetterslev J, Thorlund K, Brok J, Gluud C. Estimating required information size by quantifying diversity in a random-effects meta-analysis. BMC Medical Research Methodology 2009;9:86.
Wood 2008
  • Wood L, Egger M, Gluud LL, Schulz KF, Jüni P, Altman GD, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ (Clinical Research Ed.) 2008;336:601-5.
Zoli 1996