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Topical application of tranexamic acid for the reduction of bleeding

  1. Katharine Ker*,
  2. Deirdre Beecher,
  3. Ian Roberts

Editorial Group: Cochrane Injuries Group

Published Online: 23 JUL 2013

Assessed as up-to-date: 31 MAY 2013

DOI: 10.1002/14651858.CD010562.pub2


How to Cite

Ker K, Beecher D, Roberts I. Topical application of tranexamic acid for the reduction of bleeding. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD010562. DOI: 10.1002/14651858.CD010562.pub2.

Author Information

  1. London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

*Katharine Ker, Cochrane Injuries Group, London School of Hygiene & Tropical Medicine, Room 186, Keppel Street, London, WC1E 7HT, UK. katharine.ker@lshtm.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 23 JUL 2013

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Funnel plot of comparison: 1 Topical TXA versus control, outcome: 1.1 Blood loss.
[Figure 4]
Figure 4. Funnel plot of comparison: 1 Topical TXA versus control, outcome: 1.8 Blood transfusion.
[Figure 5]
Figure 5. Summary of findings table and GRADE evidence profile: Should topical TXA be used for the reduction of surgical bleeding?
[Analysis 1.1]
Analysis 1.1. Comparison 1 Topical tranexamic acid versus control, Outcome 1 Blood loss.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Topical tranexamic acid versus control, Outcome 2 Estimated blood loss.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Topical tranexamic acid versus control, Outcome 3 Mortality.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Topical tranexamic acid versus control, Outcome 4 Myocardial infarction.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Topical tranexamic acid versus control, Outcome 5 Stroke.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Topical tranexamic acid versus control, Outcome 6 Deep vein thrombosis.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Topical tranexamic acid versus control, Outcome 7 Pulmonary embolism.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Topical tranexamic acid versus control, Outcome 8 Blood transfusion.