Intervention Protocol

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Metformin for women who are obese during pregnancy for improving maternal and infant outcomes

  1. Amanda J Eames1,*,
  2. Rosalie M Grivell1,
  3. Andrea R Deussen1,
  4. William Hague2,
  5. Jodie M Dodd3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 18 JUN 2013

DOI: 10.1002/14651858.CD010564

How to Cite

Eames AJ, Grivell RM, Deussen AR, Hague W, Dodd JM. Metformin for women who are obese during pregnancy for improving maternal and infant outcomes (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010564. DOI: 10.1002/14651858.CD010564.

Author Information

  1. 1

    The University of Adelaide, Women's and Children's Hospital, Discipline of Obstetrics and Gynaecology, Adelaide, Australia

  2. 2

    Women's and Children's Hospital, Adelaide, South Australia, Australia

  3. 3

    The University of Adelaide, School of Paediatrics and Reproductive Health, Discipline of Obstetrics and Gynaecology, Adelaide, South Australia, Australia

*Amanda J Eames, Discipline of Obstetrics and Gynaecology, The University of Adelaide, Women's and Children's Hospital, 72 King William Road, Adelaide, 5006, Australia. ajeames@yahoo.com.au.

Publication History

  1. Publication Status: New
  2. Published Online: 18 JUN 2013

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References

Additional references

Alwan 2009
Bailey 1996
  • Bailey CJ, Turner RC. Metformin. New England Journal of Medicine 1996;334:574-9.
Beyerlein 2011
Callaway 2006
  • Callaway LK, Prins JB, Chang AM, McIntyre HD. The prevalence and impact of overweight and obesity in an Australian obstetric population. Medical Journal of Australia 2006;184(2):56-9.
Caro 1996
Catalano 2011
  • Catalano PM, Hauguel-De Mouzon S. Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic?. American Journal of Obstetrics & Gynecology 2011;204(6):479-87.
Cedergren 2004
Cedergren 2007
Chan 2009
  • Chan A, Scheil W, Scott J, Nguyen A-M, Sage L. Pregnancy Outcome in South Australia. Pregnancy Outcome Unit, SA Health, Government of South Australia, 2009.
Chen 2008
Crane 2009
  • Crane JM, White J, Murphy P. The effect of gestational weight gain by body mass index on maternal and neonatal outcomes. Journal of Obstetrics and Gynaecology Canada 2009;31:28-35.
Cusi 1998
Dodd 2011
Ehrenberg 2004
Ezzati 2002
Furber 2013
  • Furber C, McGowan L, Bower P, Kontopantelis E, Quenby S, Lavender T. Antenatal interventions for reducing weight in obese women for improving pregnancy outcome. Cochrane Database of Systematic Reviews 2013, Issue 1. [DOI: 10.1002/14651858.CD009334]
Galtier-Dereure 1995
  • Galtier-Dereure F, Montpeyroux F, Boulot P, Bringer J, Jaffiol C. Weight excess before pregnancy: complications and cost. International Journal of Obesity and Related Metabolic Disorders 1995;19:443-8.
Gilbert 2006
Greenberg 2006
  • Greenberg AS. Obesity and the role of adipose tissue in inflammation and metabolism. American Journal of Clinical Nutrition 2006;83:461-5.
Hawthorne 2006
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hundal 2000
Institute of Medicine 2009
  • Institute of Medicine. Weight Gain During Pregnancy: Re-examining the Guidelines. Washington, DC: National Academies Press, 2009.
Inzucchi 1998
  • Inzucchi SE, Maggs DG, Spollett GR, Page SL, Rife FS, Walton V, et al. Efficacy and metabolic effects of metformin and troglitazone in type 2 diabetes mellitus. New England Journal of Medicine 1998;338:867-72.
Ismail 2012
  • Ismail KMK, Issa BG, Jones P, Hanna FW, Indusekhar R. Hypoglycaemic agents for pregnant women with polycystic ovarian syndrome. Cochrane Database of Systematic Reviews 2012, Issue 5. [DOI: 10.1002/14651858.CD009828]
Kiel 2007
Kirpichnikov 2002
  • Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Annals of Internal Medicine 2002;137:25-33.
Large 1999
Levri 2005
  • Levri KM, Slaymaker E, Last A, Yeh J, Ference J, D'Amico F, et al. Metformin as treatment for overweight and obese adults: a systematic review. Annals of Family Medicine 2005;3(5):457-61.
Lilja 2006
Lyon 2001
McConway 2000
  • McConway MG, Johnson D, Kelly A, Griffen D, Smith J, Wallace AM. Differences in circulating concentrations of total, free and bound leptin relate to gender and body composition in adult humans. Annals of Clinical Biochemistry 2000;37:717-23.
Nieuwenhuis-Ruifrok 2009
  • Nieuwenhuis-Ruifrok AE, Kuchenbecker WKH, Hoek A, Middleton P, Norman RJ. Insulin sensitizing drugs for weight loss in women of reproductive age who are overweight or obese: a systematic review and meta-analysis. Human Reproduction Update 2009;15(1):57-68.
Ogden 2006
Oken 2009
  • Oken E, Kleinman KP, Belfort MB. Associations of gestational weight gain with short- and longer-term maternal and child health outcomes. American Journal of Epidemiology 2009;170:173-80.
Pedersen 1954
Perriello 1994
  • Perriello G, Misericordia P, Volpi E, Santucci A, Santucci C, Ferrannini E, et al. Acute antihyperglycemic mechanisms of metformin in NIDDM. Evidence for suppression of lipid oxidation and hepatic glucose production. Diabetes 1994;43:920-8.
Ramsay 2002
  • Ramsay JE, Ferrell WR, Crawford L, Wallace AM, Greer IA, Sattar N. Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways. Journal of Clinical Endocrinology and Metabolism 2003;87(9):4231-7.
RevMan 2011
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Sebire 2001
  • Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW. Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. International Journal of Obesity and Related Metabolic Disorders 2001;25:1175-82.
Thompson 2001
Wang 2008
Wang 2011
  • Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet 2011;378(9805):1778.
Weiss 2004
  • Weiss JL, Malone FD, Emig D, Ball RH, Nyberg DA, Comstock CH. Obesity, obstetric complications and caesarean delivery rate - a population-based screening study. American Journal of Obstetrics and Gynecology 2004;190:1091-7.
Wiernsperger 1999
Withrow 2009
World Health Organization 2000
  • WHO. Obesity: Preventing and Managing the Global Epidemic. WHO Technical Report Series. Number 894. Geneva (Switzerland): WHO, 2000.
World Health Organization 2009
  • Mathers C, Stevens G, Mascarenhas M. Global Health Risks: Mortality and Burden of Disease Attributable to Selected Major Risks. Geneva (Switzerland): WHO, 2009.
Yu 2006