This is the protocol for a review and there is no abstract. The objectives are as follows:
We aim to perform a systematic review and meta-analysis to assess the effectiveness of prehospital initiation of therapeutic hypothermia in comparison to later or in-hospital initiation of therapeutic hypothermia in patients with prehospital cardiac arrest. Our primary outcome measures, among other patient-relevant variables, are survival and neurologic outcome. We plan to undertake subgroup analyses according to the mode of therapeutic hypothermia and the cardiac arrest situation, and sensitivity analyses to assess the robustness of our estimates.