Intervention Protocol

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Total thyroidectomy versus subtotal thyroidectomy for Graves' disease

  1. Zi Wei Liu1,*,
  2. Liam Masterson2,
  3. Piyush Jani2,
  4. Brian Fish3,
  5. Krishna Chatterjee3

Editorial Group: Cochrane Metabolic and Endocrine Disorders Group

Published Online: 7 OCT 2013

DOI: 10.1002/14651858.CD010576

How to Cite

Liu ZW, Masterson L, Jani P, Fish B, Chatterjee K. Total thyroidectomy versus subtotal thyroidectomy for Graves' disease (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD010576. DOI: 10.1002/14651858.CD010576.

Author Information

  1. 1

    Broomfield Hospital, Otolaryngology - Head and Neck Surgery, Chelmsford, Essex, UK

  2. 2

    Cambridge University Hospitals NHS Foundation Trust, ENT Department, Cambridge, UK

  3. 3

    Cambridge Biomedical Campus, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK

*Zi Wei Liu, Otolaryngology - Head and Neck Surgery, Broomfield Hospital, Court Road, Chelmsford, Essex, CM1 7ET, UK.

Publication History

  1. Publication Status: New
  2. Published Online: 7 OCT 2013



Additional references

Al-Adhami 2012
  • Al-Adhami A, Craig W, Krukowski ZH. Quality of life after surgery for Graves' disease: comparison of those having surgery intended to preserve thyroid function with those having ablative surgery. Thyroid 2012;22(5):494-500. [PUBMED: 22420618]
Barczynski 2011
  • Barczyński M, Konturek A, Stopa M, Cichoń S, Richter P, Nowak W. Total thyroidectomy for benign thyroid disease: is it really worthwhile?. Annals of Surgery 2011;254(5):724-9. [PUBMED: 22005150]
Bellantone 2002
  • Bellantone R, Lombardi CP, Bossola M, Boscherini M, De Crea C, Alesina P. Total thyroidectomy for management of benign thyroid disease: review of 526 cases. World Journal of Surgery 2002;26(12):1468-71. [PUBMED: 12360381]
Brandt 2011
  • Brandt F, Green A, Hegedüs L, Brix TH. A critical review and meta-analysis of the association between overt hyperthyroidism and mortality. European Journal of Endocrinology/European Federation of Endocrine Societies 2011;165(4):491-7. [PUBMED: 21724839]
Chi 2005
  • Chi SY, Hsei KC, Sheen-Chen SM, Chou FF. A prospective randomized comparison of bilateral subtotal thyroidectomy versus unilateral total and contralateral subtotal thyroidectomy for graves' disease. World Journal of Surgery 2005;29(2):160-3. [PUBMED: 15650802]
De Bellis 2012
  • De Bellis A, Conzo G, Cennamo G, Pane E, Bellastella G, Colella C. Time course of Graves' ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal study. Endocrine 2012;41(2):320-6. [PUBMED: 22169963]
Efremidou 2009
  • Efremidou EI, Papageorgiou MS, Liratzopoulos N, Manolas KJ. The efficacy and safety of total thyroidectomy in the management of benign thyroid disease: a review of 932 cases. Canadian Journal of Surgery 2009;52(1):39-44. [PUBMED: 19234650]
Genovese 2012
  • Genovese BM, Noureldine SI, Gleeson EM, Tufano RP, Kandil E. What is the best definitive treatment for Graves' disease? A systematic review of the existing literature. Annals of Surgical Oncology 2012;20(2):660-7. [DOI: 10.1245/s10434-012-2606-x]
Hermann 1998
  • Hermann M, Roka R, Richter B, Freissmuth M. Early relapse after operation for Graves' disease: postoperative hormone kinetics and outcome after subtotal, near-total, and total thyroidectomy. Surgery 1998;124(5):894-900. [: 9823404]
Higgins 2002
Higgins 2003
Higgins 2009
Higgins 2011a
  • Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.
Higgins 2011b
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Hróbjartsson 2013
  • Hróbjartsson A, Thomsen AS, Emanuelsson F, Tendal B, Hilden J, Boutron I, et al. Observer bias in randomized clinical trials with measurement scale outcomes: a systematic review of trials with both blinded and nonblinded assessors. Canadian Medical Association Journal 2013;185(4):E201-11.
In 2009
  • In H, Pearce EN, Wong AK, Burgess JF, McAneny DB, Rosen JE. Treatment options for Graves disease: a cost-effectiveness analysis. Journal of the American College of Surgeons 2009;209(2):170-9. [PUBMED: 19632593]
Kirkham 2010
Lalwani 2012
  • Lalwani K. Lange Current Diagnosis and Treatment: Otolaryngology - Head and Neck Surgery. 3rd Edition. McGraw-Hill, 2012.
Laurberg 2012
  • Laurberg P, Berman DC, Bülow Pedersen I, Andersen S, Carlé A. Incidence and clinical presentation of moderate to severe graves' orbitopathy in a Danish population before and after iodine fortification of salt. Journal of Clinical Endocrinology and Metabolism 2012;97(7):2325-32. [PUBMED: 22518849]
Leo 2012
  • Leo M, Marcocci C, Pinchera A, Nardi M, Megna L, Rocchi R. Outcome of Graves' orbitopathy after total thyroid ablation and glucocorticoid treatment: follow-up of a randomized clinical trial. Journal of Clinical Endocrinology and Metabolism 2012;97(1):E44-8. [PUBMED: 22031515]
Liberati 2009
Palit 2000
Paunkovic 2007
  • Paunkovic N, Paunkovic J. The diagnostic criteria of Graves' disease and especially the thyrotropin receptor antibody; our own experience. Hellenic Journal of Nuclear Medicine 2007;10(2):89-94. [PUBMED: 17684583]
Ponto 2012
  • Ponto Ka, Kahaly GJ. Autoimmune thyrotoxicosis: diagnostic challenges. American Journal of Medicine 2012;125(9):S1. [PUBMED: 22938935]
Riley 2011
  • Riley RD, Higgins JP, Deeks JJ. Interpretation of random effects meta-analyses. BMJ 2011;342:d549.
Sterne 2011
  • Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 2011;343:d4002.
Wood 2008
  • Wood L, Egger M, Gluud LL, Schulz KF, Juni P, Altman DG, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ 2008;336(7644):601-5.
Zanocco 2012
  • Zanocco K, Heller M, Elaraj D, Sturgeon C. Is subtotal thyroidectomy a cost-effective treatment for Graves disease? A cost-effectiveness analysis of the medical and surgical treatment options. Surgery 2012;152(2):164-72. [PUBMED: 22503512]