Intervention Protocol

You have free access to this content

Combination pharmacotherapy for the treatment of fibromyalgia

  1. Ian Gilron1,*,
  2. Bonnie Shum2,
  3. R Andrew Moore3,
  4. Philip J Wiffen3

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 13 JUN 2013

DOI: 10.1002/14651858.CD010585

How to Cite

Gilron I, Shum B, Moore RA, Wiffen PJ. Combination pharmacotherapy for the treatment of fibromyalgia (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010585. DOI: 10.1002/14651858.CD010585.

Author Information

  1. 1

    Queen's University, Departments of Anesthesiology & Perioperative Medicine & Biomedical & Molecular Sciences, Kingston, ON, Canada

  2. 2

    Queens University, Anesthesiology & perioperative Medicine, Kingston, ON, Canada

  3. 3

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

*Ian Gilron, Departments of Anesthesiology & Perioperative Medicine & Biomedical & Molecular Sciences, Queen's University, 76 Stuart Street, Victory 2 Pavillion, Kingston, ON, K7L 2V7, Canada.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 13 JUN 2013



Additional references

Arnold 2012
  • Arnold LM, Clauw DJ, Dunegan LJ, Turk DC, FibroCollaborative. A framework for fibromyalgia management for primary care providers. Mayo Clinic Proceedings 2012;87(5):488-96.
Berger 2007
Chaparro 2012
Derry 2012
Dworkin 2008
  • Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, et al. Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations. Journal of Pain 2008;9(2):105-21.
Goldenberg 2004
Gran 2003
Hauser 2009a
Hearn 2012
Häuser 2009b
  • Häuser W, Bernardy K, Uçeyler N, Sommer C. Treatment of fibromyalgia syndrome with gabapentin and pregabalin--a meta-analysis of randomized controlled trials. Pain 2009;145(1-2):69-81.
Hüppe 2004
  • Hüppe A, Brockow T, Raspe H. Chronic widespread pain and tender points in low back pain: a population-based study. Zeitschrift für Rheumatologie 2004;63(1):76-83.
Ifergane 2006
Jadad 1996
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 1996 Feb;17(1):1-12.
L'Abbé 1987
Lunn 2009
  • Lunn MP, Hughes RA, Wiffen PJ. Duloxetine for treating painful neuropathy or chronic pain.. Cochrane Database Syst Rev. 2009 Oct 7;4(CD007115.):doi: 10.1002/14651858.CD007115.
McQuay 1998
  • McQuay H, Moore R. An Evidence-based Resource for Pain Relief. Oxford: Oxford University Press, 1998. [ISBN: 0-19-263048-2]
Mease 2008
Moore 2008
  • Moore RA, Barden J, Derry S, McQuay HJ. Managing potential publication bias. In: McQuay HJ, Kalso E, Moore RA editor(s). Systematic Reviews in Pain Research: Methodology Refined. Seattle: IASP Press, 2008:15-24. [ISBN: 978–0–931092–69–5]
Moore 2009
Moore 2010a
  • Moore RA, Straube S, Paine J, Phillips CJ, Derry S, McQuay HJ. Fibromyalgia: Moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain. Pain 2010;149(2):360-4.
Moore 2011
  • Moore RA, Wiffen PJ, Derry S, McQuay HJ. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database of Systematic Reviews 2011, Issue 3. [DOI: 10.1002/14651858.CD007938.pub2]
Moore 2012a
Moore 2012b
O'Brien 2010
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Silverman 2009
  • Silverman S, Dukes EM, Johnston SS, Brandenburg NA, Sadosky A, Huse DM. The economic burden of fibromyalgia: comparative analysis with rheumatoid arthritis. Current Medical Research and Opinion 2009;25(4):829-40.
Straube 2011
Sultan 2008
White 1999
  • White KP, Speechley M, Harth M, Ostbye T. The London Fibromyalgia Epidemiology Study: direct health care costs of fibromyalgia syndrome in London, Canada. Journal of Rheumatology 1999;26(4):885-9.
Wolfe 1995
Wolfe 2009