Intervention Protocol

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Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults

  1. Qurrat U Mehmood1,*,
  2. Kate Garcez2,
  3. Caroline C Henson3,
  4. Susan E Davidson2,
  5. Claire E Higham4

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 28 JUN 2013

DOI: 10.1002/14651858.CD010604


How to Cite

Mehmood QU, Garcez K, Henson CC, Davidson SE, Higham CE. Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010604. DOI: 10.1002/14651858.CD010604.

Author Information

  1. 1

    Christie Hospital NHS Foundation Trust, Radiotherapy-related Research, Manchester, Greater Manchester, UK

  2. 2

    Christie Hospital NHS Foundation Trust, Clinical Oncology, Manchester, UK

  3. 3

    Royal Bolton Hospital, Gastroenterology, Bolton, Lancashire, UK

  4. 4

    Christie Hospital NHS Foundation Trust, Endocrinology, Manchester, Greater Manchester, UK

*Qurrat U Mehmood, Radiotherapy-related Research, Christie Hospital NHS Foundation Trust, Wilmslow Road, Manchester, Greater Manchester, M20 4BX, UK. Q_mood@hotmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 28 JUN 2013

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The overall objective is to assess the effects of pharmacological interventions for prevention of insufficiency fractures associated with pelvic radiotherapy in adults.

Primary objective

  • To assess the effects of pharmacological interventions on insufficiency fractures and avascular necrosis of the femoral head after curative pelvic radiotherapy in adults.

Secondary objectives

  • To assess the effects of pharmacological interventions on bone mineral density and fracture risk in adults after curative pelvic radiotherapy.
  • To assess the effects of pharmacological interventions on quality of life (QoL) and bone symptoms in adults after curative pelvic radiotherapy.
  • To assess the effects of pharmacological interventions on unplanned hospital stay and mortality in adults undergoing curative pelvic radiotherapy.
  • To identify adverse effects of pharmacological interventions.
  • To compare different types of pharmacological interventions.