Intervention Review

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Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults

  1. Mattias Linde1,*,
  2. Wim M Mulleners2,
  3. Edward P Chronicle3,
  4. Douglas C McCrory4,5

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 24 JUN 2013

Assessed as up-to-date: 15 JAN 2013

DOI: 10.1002/14651858.CD010609


How to Cite

Linde M, Mulleners WM, Chronicle EP, McCrory DC. Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010609. DOI: 10.1002/14651858.CD010609.

Author Information

  1. 1

    Norwegian University of Science and Technology, Department of Neuroscience, Trondheim, Norway

  2. 2

    Canisius Wilhelmina Ziekenhuis, Department of Neurology, Nijmegen, Netherlands

  3. 3

    University of Hawaii at Manoa, (Deceased) Department of Psychology, Manoa, USA

  4. 4

    Duke University Medical Center, Department of Medicine, Durham, NC, USA

  5. 5

    Durham Veterans Affairs Medical Center, Center for Health Services Research in Primary Care, Durham, NC, USA

*Mattias Linde, Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. mattias.linde@ntnu.no.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 24 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Di Trapani 2000 {published and unpublished data}
  • Di Trapani G, Mei D, Marra C, Mazza S, Capuano A. Gabapentin in the prophylaxis of migraine: a double-blind randomized placebo-controlled study. Clinica Terapeutica 2000;151(3):145-8. [MEDLINE: 10958046]
Jimenez 2002 {published data only}
  • Jimenez-Hernandez MD, Torrecillas-Narvaez MD, Friera-Acebal G. Effectiveness and safety of gabapentin in the preventive treatment of migraine [Eficacia y seguridad de la gabapentina en el tratamiento preventivo de la migrana]. Revista de Neurologia 2002;35(7):603-6. [MEDLINE: 12389143]
RR 4301-00066 {unpublished data only}
  • Feuerstein T, Quebe-Fehling E. A double-blind, placebo-controlled, parallel-group, multicenter study of the safety and efficacy of gabapentin (CI-945) as a prophylactic interval therapy in patients with common migraine (Protocols 879-201, -205, -206, -207, -209). Research Report No. RR 4301-00066. Freiburg: Goedecke AG Research and Development; June 25, 1990. Available at: http://dida.library.ucsf.edu/pdf/crr13j10.
RR 995-00074 {published data only}
  • Magnus-Miller L, Bernstein P, Caswell K. Double-blind, randomized, placebo-controlled, multicenter trial to determine the efficacy and safety of Neurontin® (gabapentin) in migraine prophylaxis administered in doses divided three times a day (TID) (Protocol 945-220). Research Report No. RR 995-00074. Morris Plains, NJ: Parke-Davis Pharmaceutical Research Division of Warner-Lambert Company Medical and Scientific Affairs Department; August 24, 1999. Available at: http://dida.library.ucsf.edu/pdf/arr13j10.
RR 995-00085 {unpublished data only}
  • Magnus-Miller L, Bernstein P, Caswell K. Double-blind, randomized, placebo-controlled, multicenter trial to determine the efficacy and safety of Neurontin® (gabapentin) in migraine prophylaxis (Protocol 945-217). Research Report No. RR 995-00085. Morris Plains, NJ: Parke-Davis Pharmaceutical Research Division of Warner-Lambert Company Medical and Scientific Affairs Department; January 20, 2000. Available at: http://dida.library.ucsf.edu/pdf/brr13j10.
Silberstein 2013 {published data only (unpublished sought but not used)}
  • Silberstein S, Goode-Sellers S, Twomey C, Saiers J, Ascher J. Randomized, double-blind, placebo-controlled, phase II trial of gabapentin enacarbil for migraine prophylaxis. Cephalagia 2013;33(2):101-11. [MEDLINE: 23165696]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Cutrer 2001 {published data only}
Jimenez 1999 {published data only}
  • Jimenez MD, Freira G, Morales A, Cuartero F, Morralla C, Sol JM, et al. Gabapentine in the prophylaxis of migraine. A pilot study [Gabapentina en la profilaxis de la migrana. Estudio piloto]. Neurologia 1999;14(10):478.
Mathew 2001 {published data only}
Merren 1998 {published data only}
  • Merren MD. Gabapentin for treatment of pain and tremor: a large case series. Southern Medical Journal 1998;91(8):739-44. [MEDLINE: 9715219]
Spira 2003 {published data only}
  • Spira PJ, Beran RG, Australian Gabapentin Chronic Daily Headache Group. Gabapentin in the prophylaxis of chronic daily headache: a randomized, placebo-controlled study. Neurology 2003;61(12):1753-9. [MEDLINE: 14694042]
Wessely 1987 {published data only}
  • Wessely P, Baumgartner C, Klingler D, Kreczi J, Meyerson N, Sailer L, et al. Preliminary results of a double blind study with the new migraine prophylactic drug gabapentin. Cephalalgia 1987;7 Suppl 6:476-7.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ad Hoc Cttee 1962
  • Ad Hoc Committee on the Classification of Headache of the National Institute of Neurological Diseases and Blindness. Classification of headache. JAMA 1962;179(9):717-8.
Alderson 2004
  • Alderson P, Green S, Higgins JPT, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Reviewers' Handbook 4.2.2 [updated December 2003]; Appendix 5b. In: The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
Clarke 1996
  • Clarke CE, MacMillan L, Sondhi S, Wells NE. Economic and social impact of migraine. QJM 1996;89(1):77-84. [MEDLINE: 8730346]
Dalkara 2012
  • Dalkara S, Karakurt A. Recent progress in anticonvulsant drug research: strategies for anticonvulsant drug development and applications of antiepileptic drugs for non-epileptic central nervous system disorders. Current Topics in Medicinal Chemistry 2012;12(9):1033-71. [MEDLINE: 22352861]
Drugs.com 2013
  • Gabapentin User Reviews for Migraine at Drugs.com. http://www.drugs.com/comments/gabapentin/for-migraine.html (accessed 11 April 2013).
Edmeads 1993
  • Edmeads J, Findlay H, Tugwell P, Pryse-Phillips W, Nelson RF, Murray TJ. Impact of migraine and tension-type headache on life-style, consulting behaviour, and medication use: a Canadian population survey. Canadian Journal of Neurological Sciences 1993;20(2):131-7. [MEDLINE: 8334575]
Evers 2009
GBD 2010 Study
  • Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013;380(9859):2163-96. [MEDLINE: 23245607]
Hollis 1999
  • Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomised controlled trials. BMJ 1999;319(7211):670-4. [MEDLINE: 10480822]
ICHD-II 2004
  • Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004;24 Suppl 1:1-160.
IHS Cttee 1988
  • Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988;8 Suppl 7:1-96.
Jadad 1996
Landefeld 2009
Linde 2012
Linde 2013a
  • Linde M, Mulleners WM, Chronicle EP, McCrory DC. Topiramate for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD010610]
Linde 2013b
Linde 2013c
  • Linde M, Mulleners WM, Chronicle EP, McCrory DC. Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD010609]
Linde 2013d
  • Linde M, Mulleners WM, Chronicle EP, McCrory DC. Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD010608]
Mayo Clinic Staff 2011
  • Mayo Clinic Staff. Migraine: Treatments and drugs. http://www.mayoclinic.com/health/migraine-headache/DS00120/DSECTION=treatments-and-drugs 2011 June 4 (accessed 11 April 2013).
McCrory 2008
  • McCrory DC. Report on gabapentin (Neurontin) for migraine prophylaxis: evaluation of efficacy, effectiveness and marketing. Expert consultant’s report. August 11, 2008. Available at: http://dida.library.ucsf.edu/pdf/oxx18q10.
McQuay 1998
  • McQuay H, Moore R. An Evidence-based Resource for Pain Relief. Oxford: Oxford University Press, 1998.
Mehuys 2012
Olesen 2006
  • Olesen J, Bousser M-G, Diener H-C, Dodick D, First M, Goadsby PJ, et al. Headache Classification Committee. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 2006;26(6):742-6. [MEDLINE: 16686915]
Porter 1992
  • Porter RJ, Meldrum BS. Antiepileptic drugs. In: Katzung BG editor(s). Basic and Clinical Pharmacology. 5th Edition. Norwalk, CT: Appleton & Lange, 1992:331-49.
Pringsheim 2012
  • Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, Christie SN, et al. Canadian Headache Society Prophylactic Guidelines Development Group. Canadian Headache Society guideline for migraine prophylaxis. Canadian Journal of Neurological Sciences 2012;39(2 Suppl 2):S1-59. [MEDLINE: 22683887]
Saris 2010
  • U.S.D.J, Saris P. Findings of fact and conclusions of law, In re Neurontin Marketing and Sales Practices Litigation. Civil Action No. 04-cv-10739-PBS, 2010 WL 4325225; 3 November 2010. Available at: http://pacer.mad.uscourts.gov/dc/cgi-bin/recentops.pl?filename=saris/pdf/ucl%20opinion.pdf.
Silberstein 2008
Silberstein 2012
  • Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E, Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology 2012;78(17):1337-45. [MEDLINE: 22529202]
Tfelt-Hansen 2012
  • Tfelt-Hansen P, Pascual J, Ramadan N, Dahlöf C, D'Amico D, Diener HC, et al. International Headache Society Clinical Trials Subcommittee. Guidelines for controlled trials of drugs in migraine: third edition. A guide for investigators. Cephalalgia 2012;32(1):6-38. [MEDLINE: 22384463]
Vedula 2009
Victor 2003
  • Victor S, Ryan S. Drugs for preventing migraine headaches in children. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD002761]
Wiffen 2010

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chronicle 2004
Mulleners 2008