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Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults

  1. Mattias Linde1,*,
  2. Wim M Mulleners2,
  3. Edward P Chronicle3,
  4. Douglas C McCrory4,5

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 24 JUN 2013

Assessed as up-to-date: 15 JAN 2013

DOI: 10.1002/14651858.CD010611


How to Cite

Linde M, Mulleners WM, Chronicle EP, McCrory DC. Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD010611. DOI: 10.1002/14651858.CD010611.

Author Information

  1. 1

    Norwegian University of Science and Technology, Department of Neuroscience, Trondheim, Norway

  2. 2

    Canisius Wilhelmina Ziekenhuis, Department of Neurology, Nijmegen, Netherlands

  3. 3

    University of Hawaii at Manoa, (Deceased) Department of Psychology, Manoa, USA

  4. 4

    Duke University Medical Center, Department of Medicine, Durham, NC, USA

  5. 5

    Durham Veterans Affairs Medical Center, Center for Health Services Research in Primary Care, Durham, NC, USA

*Mattias Linde, Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway. mattias.linde@ntnu.no.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 24 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Afshari 2012 {published data only (unpublished sought but not used)}
  • Afshari D, Rafizadeh S, Rezaei M. A comparative study of the effects of low-dose topiramate versus sodium valproate in migraine prophylaxis. International Journal of Neuroscience 2012;122(2):60-8. [MEDLINE: 21950578]
Freitag 2002 {published data only}
  • Freitag FG, Collins SD, Carlson HA, Goldstein J, Saper J, Silberstein S, et al. A randomized trial of divalproex sodium extended-release tablets in migraine prophylaxis. Neurology 2002;58(11):1652-9. [MEDLINE: 12058094]
Hering 1992 {published data only}
Jensen 1994 {published data only}
  • Jensen R, Brinck T, Olesen J. Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study. Neurology 1994;44(4):647-51. [MEDLINE: 8164818]
Kaniecki 1997 {published data only}
  • Kaniecki RG. A comparison of divalproex with propanolol and placebo for the prophylaxis of migraine without aura. Archives of Neurology 1997;54(9):1141-5. [MEDLINE: 9311358]
Kinze 2001 {published data only}
Klapper 1997 {published data only}
  • Klapper J, on behalf of the Divalproex Sodium in Migraine Prophylaxis Study Group. Divalproex sodium in migraine prophylaxis: a dose-controlled study. Cephalalgia 1997;17(2):103-8. [MEDLINE: 9137847]
    Direct Link:
Mathew 1995 {published data only}
  • Mathew NT, Saper JR, Silberstein SD, Rankin L, Markley HG, Solomon S, et al. Migraine prophylaxis with divalproex. Archives of Neurology 1995;52(3):281-6. [MEDLINE: 7872882]
Mitsikostas 1997 {published data only}
  • Mitsikostas DD, Polychronidis I. Valproate versus flunarizine in migraine prophylaxis: a randomized, double-open, clinical trial. Functional Neurology 1997;12(5):267-76. [MEDLINE: 9439944]
Shaygannejad 2006 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Arnold 1998 {published data only}
Bartolini 2005 {published data only}
Bavrasad 2010 {published data only}
  • Bavrasad R, Nejad SEM, Yarahmadi AR, Sajedi SI, Rahim F. Assessment of the middle dose of topiramate in comparison with sodium valproate for migraine prophylaxis: a randomized double-blind study. International Journal of Pharmacology 2010;6(5):670-5. [EMBASE: 2010449325]
Blumenfeld 2008 {published data only}
Cutrer 2001 {published data only}
Erdemoglu 2000 {published data only}
  • Erdemoglu AK, Ozbakir S. Valproic acid in prophylaxis of refractory migraine. Acta Neurologica Scandinavica 2000;102(6):354-8. [MEDLINE: 11125749]
    Direct Link:
Fragoso 2003 {published data only}
  • Fragoso YD. Low dose of sodium divalproate for the treatment of migraine. MedGenMed [electronic resource]: Medscape General Medicine 2003;5(1):32. [MEDLINE: 12827093]
Ghose 1998 {published data only}
Green 2005 {published data only}
Keyvan 2009 {published and unpublished data}
  • Keyvan G, Abolfazl MB. Comparison of treatment effect of sodium valproate, propranolol and tricyclic antidepressants in migraine. Pakistan Journal of Biological Sciences 2009;12(15):1098-101. [MEDLINE: 19943469]
Klapper 1994 {published data only}
  • Klapper JA. An open label cross-over comparison of divalproex sodium and propanolol HCl in the prevention of migraine headaches. Headache Quarterly 1994;5(4):50-3.
Krymchantowski 2011 {published data only}
Lenaerts 1996 {published data only}
  • Lenaerts M, Bastings E, Sianard J, Schoenen J. Sodium valproate in severe migraine and tension-type headache: an open study of long-term efficacy and correlation with blood levels. Acta Neurologica Belgica 1996;96(2):126-9. [MEDLINE: 8711985]
Millan-Guerrero 2007 {published data only}
Rothrock 1994 {published data only}
Rothrock 1997 {published data only}
Silberstein 1993 {published data only}
  • Silberstein SD, Saper JR, Mathew NT. The safety and efficacy of divalproex sodium in the prophylaxis of migraine headache: a multicenter, double-blind, placebo-controlled trial. Headache 1993;33(5):264-5.
Sørensen 1988 {published data only}
Togha 2008 {published data only}
  • Togha M, Rahmat Jirde M, Nilavari K, Ashrafian H, Razeghi S, et al. Cinnarizine in refractory migraine prophylaxis: Efficacy and tolerability. A comparison with sodium valproate. Journal of Headache & Pain 2008;9(2):77-82. [MEDLINE: 18286231]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Ad Hoc Cttee 1962
  • Ad Hoc Committee on the Classification of Headache of the National Institute of Neurological Diseases and Blindness. Classification of headache. JAMA 1962;179(9):717-8.
Alderson 2004
  • Alderson P, Green S, Higgins JPT, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Reviewers' Handbook 4.2.2 [updated December 2003]; Appendix 5b. In: The Cochrane Library, Issue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
Clarke 1996
  • Clarke CE, MacMillan L, Sondhi S, Wells NE. Economic and social impact of migraine. QJM 1996;89(1):77-84. [MEDLINE: 8730346]
Cutrer 1997
Dalkara 2012
  • Dalkara S, Karakurt A. Recent progress in anticonvulsant drug research: strategies for anticonvulsant drug development and applications of antiepileptic drugs for non-epileptic central nervous system disorders. Current Topics in Medicinal Chemistry 2012;12(9):1033-71. [MEDLINE: 22352861]
Edmeads 1993
  • Edmeads J, Findlay H, Tugwell P, Pryse-Phillips W, Nelson RF, Murray TJ. Impact of migraine and tension-type headache on life-style, consulting behaviour, and medication use: a Canadian population survey. Canadian Journal of Neurological Sciences 1993;20(2):131-7. [MEDLINE: 8334575]
Edvinsson 2010
Evers 2009
GBD 2010 Study
  • Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2013;380(9859):2163-96. [MEDLINE: 23245607]
ICHD-II 2004
  • Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd edition. Cephalalgia 2004;24 Suppl 1:1-160.
IHS Cttee 1988
  • Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988;8 Suppl 7:1-96.
Jadad 1996
Linde 2004
Linde 2012
Linde 2013a
  • Linde M, Mulleners WM, Chronicle EP, McCrory DC. Topiramate for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD010610]
Linde 2013b
Linde 2013c
  • Linde M, Mulleners WM, Chronicle EP, McCrory DC. Gabapentin or pregabalin for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD010609]
Linde 2013d
  • Linde M, Mulleners WM, Chronicle EP, McCrory DC. Antiepileptics other than gabapentin, pregabalin, topiramate, and valproate for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews 2013, Issue 6. [DOI: 10.1002/14651858.CD010608]
McQuay 1998
  • McQuay H, Moore R. An Evidence-based Resource for Pain Relief. Oxford: Oxford University Press, 1998.
Mehuys 2012
Morrell 2003
Olesen 2006
  • Olesen J, Bousser M-G, Diener H-C, Dodick D, First M, Goadsby PJ, et al. Headache Classification Committee. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia 2006;26(6):742-6. [MEDLINE: 16686915]
Porter 1992
  • Porter RJ, Meldrum BS. Antiepileptic drugs. In: Katzung BG editor(s). Basic and Clinical Pharmacology. 5th Edition. Norwalk, CT: Appleton & Lange, 1992:331-49.
Reveiz-Herault 2003
  • Reveiz-Herault L, Cardona AF, Ospina EG, Carrillo P. Effectiveness of flunarizine in the prophylaxis of migraine: a meta-analytical review of the literature [Eficacia de flunaricina en la profilaxis de migrana: revision metaanalitica de la bibliografia]. Revista de Neurologia 2003;36(10):907-12. [MEDLINE: 12766861]
Silberstein 2008
Silberstein 2012
  • Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E, Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology 2012;78(17):1337-45. [MEDLINE: 22529202]
Tfelt-Hansen 2012
  • Tfelt-Hansen P, Pascual J, Ramadan N, Dahlöf C, D'Amico D, Diener HC, et al. International Headache Society Clinical Trials Subcommittee. Guidelines for controlled trials of drugs in migraine: third edition. A guide for investigators. Cephalalgia 2012;32(1):6-38. [MEDLINE: 22384463]
Victor 2003
  • Victor S, Ryan S. Drugs for preventing migraine headaches in children. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD002761]
Wiffen 2010

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chronicle 2004
Mulleners 2008