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Intervention Protocol

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Antibiotics prior to amniotomy for reducing infectious morbidity in mother and infant

  1. Amita Ray1,*,
  2. Sujoy Ray2,
  3. Aneesh Thomas George3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 1 JUL 2013

DOI: 10.1002/14651858.CD010626

How to Cite

Ray A, Ray S, George AT. Antibiotics prior to amniotomy for reducing infectious morbidity in mother and infant (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD010626. DOI: 10.1002/14651858.CD010626.

Author Information

  1. 1

    Srinivas Medical College, Department of Obstetrics and Gynaecology, Mukka, Surathkal, Mangalore, India

  2. 2

    Kasturba Medical College, Manipal University, Manipal, Karnataka, India

  3. 3

    Christian Medical College, South Asian Cochrane Network & Centre, Prof. BV Moses & ICMR Advanced Centre for Research & Training in Evidence Informed Health Care, Vellore, Tamil Nadu, India

*Amita Ray, Department of Obstetrics and Gynaecology, Srinivas Medical College, Mukka, Surathkal, Mangalore, 574146, India.

Publication History

  1. Publication Status: New
  2. Published Online: 1 JUL 2013


This is not the most recent version of the article. View current version (01 OCT 2014)


Additional references

Agency for Healthcare Research and Quality 2009
  • Agency for Healthcare Research and Quality, Rockville, MD. Maternal and neonatal outcomes of elective induction of labor. March 2009.
Bratu 2005
Bricker 2000
Busowski 1995
Calder 1999
  • Calder AA. Normal labour. In: Edmonds DK editor(s). Dewhurst’s Textbook of Obstetrics and Gynaecology for Postgraduates. 6th Edition. Blackwell Science, 1999.
Cloherty 2010
  • Cloherty JP. Bacterial and fungal infections. Manual of Neonatal care. 6th Edition. Vol. 1, New Delhi: Wolters Kluwer India. Lippincott, Williams and Wilkins, 2010:274-5.
Cooley 2010
Duff 2002
  • Duff P. Maternal and Perinatal Infections. In: Gabbe SG, Niebyl JR, Simpson JL editor(s). Obstetrics: Normal and Problem Pregnancies. 4th Edition. Philadelphia: Churchill Livingston, 2002.
Dutta 2010
  • Dutta S, Reddy R, Sheikh S, Kalra J, Ray P, Narang A. Intrapartum antibiotics and risk factors for early onset sepsis. Archives of Disease in Childhood. Fetal and Neonatal Edition 2010;95(2):99-103 .
Edwards 2005
Escobar 1999
  • Escobar GJ. The neonatal "sepsis work-up": personal reflections on the development of an evidence-based approach toward newborn infections in a managed care organization. Pediatrics 1999;103(1 Suppl E):360-73.
Falco 1969
Frigoletto 1995
Gibbs 1982
  • Gibbs RS, Blanco JD, St Clair PJ, Castaneda YS. Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term. Journal of Infectious Diseases 1982;145(1):1-8.
Gilstrap 1988
  • Gilstrap LC 3rd, Bawdon RE, Burris J. Antibiotic concentration in maternal blood, cord blood, and placental membranes in chorioamnionitis. Obstetrics and Gynecology 1988;72(1):124-5.
Goffinct 1982
Heinemann 2008
  • Heinemann J, Gillen G, Sanchez-Ramos L, Kaunitz AM. Do mechanical methods of cervical ripening increase infectious morbidity?. American Journal of Obstetrics and Gynecology 2008;199(2):177-87.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Hofmeyr 2009
  • Hofmeyr GJ, Alfirevic Z, Kelly AJ, Kavanagh J, Thomas J, Neilson JP, et al. Methods for cervical ripening and labour induction in late pregnancy: generic protocol. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD002074]
Hopkins 2002
Howarth 2001
Janes 2001
  • Janes R. Rural hospital amniotomy induction for women at or past term with a healthy pregnancy and a favourable cervix: is it a safe option?. New Zealand Medical Journal 2001;114(1128):111-3.
Katona 2008
Katzung 2007
  • Katzung B. Basic and Clinical Pharmacology. 10th Edition. New York: McGraw Hill Medical, 2007.
Kron 1995
Lamont 2006
Levine 2006
Locksmith 2005
  • Locksmith GJ, Chin A, Vu T, Shattuck KE, Hankins GD. High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels. Obstetrics and Gynecology 2005;105(3):473-9.
Mackenzie 2006
Merck 2005
  • Gentamicin: Drug Information Provided by Lexi-Comp: Merck Manual Professional. Merck Manual Professional. Lexiicomp, 2005.
Merck 2006
  • Merck, Co. l. Lincosamides, Oxazolidinones, and Streptogramins. Merck Manual of Diagnosis and Therapy. 2006.
Moellering 2006
Mozurkewich 2011
  • Mozurkewich EL, ChilimigrasJL, Berman DR, Perni UC, Romero VC, King VJ, et al. Methods of induction of labour: a systematic review. BMC Pregnancy Childbirth 2011;11(84):2-19.
Muller 1983
Nachum 2010
  • Nachum Z, Garmi G, Kadan Y, Zafran N, Shalev E, Salim R. Comparison between amniotomy, oxytocin or both for augmentation of labor in prolonged latent phase: a randomized controlled trial. Reproductive Biology and Endocrinology 2010;8:136.
Naeye 1977
Newton 1993
Pisal 2009
  • Pisal P, Lawal O, Rogers C, Shah A, Sinha S. A randomised controlled trial of amniotomy and immediate oxytocin infusion versus amniotomy and delayed oxytocin infusion for induction of labour at term. Archives of Gynecology and Obstetrics 2009;279(6):813-20.
Reilly 2008
  • Reilly SD, Faye-Petersen OM. Chorioamnionitis and Funisitis: Their Implications for the Neonate. NeoReviews [serial online]. Available at;9/9/e411 September 2008.
RevMan 2011
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Romero 1989
  • Romero R, Sirtori M, Oyarzun E, Avila C, Mazor M, Callahan R, et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. American Journal of Obstetrics and Gynecology 1989;161(3):817-24.
Rossi 2006
  • Rossi S. Australian Medicines Handbook. Adelaide: Australian Medicines Handbook, 2006.
Schuchat 1992
Silver 1989
Smyth 2007
  • Smyth RMD, Alldred SK, Markham C. Amniotomy for shortening spontaneous labour. Cochrane Database of Systematic Reviews 2007, Issue 4. [DOI: 10.1002/14651858.CD006167.pub2]
Sundin 2001
  • Sundin DP, Sandoval R, Molitoris BA. Gentamicin inhibits renal protein and phospholipid metabolism in rats: implications involving intracellular trafficking. Journal of the American Society of Nephrology 2001;12:114-23.
Tenore 2003
Thomas 2003
  • Thomas C, Stevenson M, Riley TV. Antibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review. Journal of Antimicrobial Chemotherapy 2003;51(6):1339-50.
Tinelli 2003
  • Tinelli A, Tinelli R, Tinelli FG. Induction of labour: which method to use?. Minerva Ginecologica 2003;55(6):463-82.
Tita 2010
US FDA 2009
  • Drugs at FDA.
Verani 2010
  • Verani JR, McGee L, Schrag SJ. Prevention of Group B Streptoccocal Disease. Revised Guidelines from CDC. CDC, 2010.
Wolomby 2009
  • Wolomby JJ, Tozin RR. Amniotomy for shortening spontaneous labour. RHL commentary. The WHO Reproductive Health Library. 2009.
Yoon 2001
  • Yoon BH, Romero R, Moon JB, Shim SS, Kim M, Kim G, et al. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. American Journal of Obstetrics and Gynecology 2001;185(5):1130-6.
Zanella 2010
  • Zanella P, Bogana G, Ciullo R, Zambon A, Serena A, Albertin MA. Chorioamnionitis in the delivery room. Minerva Pediatrica 2010;62(3 Suppl 1):151-3.