This is the protocol for a review and there is no abstract. The objectives are as follows:
To determine the diagnostic accuracy of the 18F-FDG-PET index test for detecting people with MCI at baseline who would clinically convert to Alzheimer’s disease or other forms of dementia at follow-up.
To investigate heterogeneity of test accuracy in the included studies.
We expect that heterogeneity will be likely and that it will be an important component of the review. The potential sources of heterogeneity, which will be used as a framework for the investigation of heterogeneity, include target population, index test, target disorder and study quality and are detailed in the analysis section.