Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies

  • Protocol
  • Diagnostic

Authors


Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

This review has two primary objectives.

Objective A: To estimate the accuracy of DAT imaging for the diagnosis of dementia with Lewy bodies (DLB) in patients with dementia in secondary care.
Objective B: To assess the value of DAT imaging in clinical practice by estimating the accuracy of DAT imaging for the diagnosis of DLB in secondary care patients with a pre-existing suspicion of DLB on the basis of a clinical work-up.

The secondary objective is to use subgroup analyses to investigate the following potential sources of heterogeneity.

(a) Age of participants.

(b) Severity of dementia. The performance of the index test itself may vary with dementia severity. For objective B, since the performance of the clinical criteria may also depend on the severity of dementia, the 'added value' to be obtained from the index test may vary significantly.

(c) For objective B, diagnostic status at inclusion (possible or probable DLB, or both).

(d) DAT imaging method (SPECT or PET, ligand).