Intervention Review

You have free access to this content

Titrated oral misoprostol for augmenting labour to improve maternal and neonatal outcomes

  1. Joshua P Vogel1,2,*,
  2. Helen M West3,
  3. Therese Dowswell3

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 23 SEP 2013

Assessed as up-to-date: 29 JUL 2013

DOI: 10.1002/14651858.CD010648.pub2


How to Cite

Vogel JP, West HM, Dowswell T. Titrated oral misoprostol for augmenting labour to improve maternal and neonatal outcomes. Cochrane Database of Systematic Reviews 2013, Issue 9. Art. No.: CD010648. DOI: 10.1002/14651858.CD010648.pub2.

Author Information

  1. 1

    World Health Organization, UNDP/UNFPA/UNICEF/WHO/Word Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research, Geneva, Switzerland

  2. 2

    University of Western Australia, School of Population Health, Faculty of Medicine, Dentistry and Health Sciences, Perth, Western Australia, Australia

  3. 3

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

*Joshua P Vogel, UNDP/UNFPA/UNICEF/WHO/Word Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research, World Health Organization, Avenue Appia 20, Geneva, CH-1211, Switzerland. vogeljo@who.int. josh.vogel00@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 23 SEP 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Bleich 2011 {published data only}
  • Bleich AT, Villano KS, Lo JY, Alexander JM, McIntire DD, Leveno KJ. Oral misoprostol for labor augmentation: a randomized controlled trial. Obstetrics and Gynecology 2011;118(6):1255-60.
Ho 2010 {published data only}
  • Ho M, Cheng SY, Li TC. Titrated oral misoprostol solution compared with intravenous oxytocin for labor augmentation: a randomized controlled trial. Obstetrics & Gynecology 2010;116(3):612-8.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Patel 2000 {published data only}
  • Patel A, Giles JM, Moffett D, Mahram R, Diro M, Burkett G. Can misoprostol be interchanged with oxytocin for augmentation of labor? [abstract]. Obstetrics & Gynecology 2000;95(4 Suppl):10S.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Aalami-Harandi 2009 {published data only}
  • Aalami-Harandi R. Comparison the effect of oral misoprostol versus oxytocin on labor augmentation in pregnant women. Iranian Registry of Clinical Trials 2009.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Abbassi 2008
  • Abbassi RM, Sirichand P, Rizvi S. Safety and efficacy of oral versus vaginal misoprostol use for induction of labour at term. Journal of the College of Physicians & Surgeons - Pakistan: JCPSP 2008;18(10):625-9.
Alfirevic 2006
Blanchard 2002
Bricker 2008
Buchmann 2006
Cheng 2006
  • Cheng SY, Chen TC. Pilot study of labor induction with titrated oral misoprostol. Taiwanese Journal of Obstetrics & Gynecology 2006;45(3):225-9.
Cheng 2008
Cheng 2010
Chibber 2011
  • Chibber R, El-Saleh E, El Harmi J. Female circumcision: obstetrical and psychological sequelae continues unabated in the 21st century. Journal of Maternal-Fetal & Neonatal Medicine 2011;24(6):833-6.
Friedman 2001
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hofmeyr 1999
Hofmeyr 2001a
Hofmeyr 2010
Hofmeyr 2011
  • Hofmeyr GJ, Gülmezoglu AM, Novikova N, Lawrie TA. Postpartum misoprostol for preventing maternal mortality and morbidity. Cochrane Database of Systematic Reviews 2011, Issue 2. [DOI: 10.1002/14651858.CD008982]
Hofmeyr 2013
Hogberg 2000
Kalogiannidis 2011
  • Kalogiannidis I, Margioula-Siarkou C, Petousis S, Masoura S, Goutzioulis A, Traianos A, et al. Parity affects pregnancy outcomes in women 35 and older. Clinical & Experimental Obstetrics & Gynecology 2011;38(2):146-9.
Kjaergaard 2008
  • Kjaergaard H, Olsen J, Ottesen B, Nyberg P, Dykes AK. Obstetric risk indicators for labour dystocia in nulliparous women: a multi-centre cohort study. BMC Pregnancy and Childbirth 2008;8:45.
Kjaergaard 2009
Konje 1990
Kundodyiwa 2009
Lawn 2009
  • Lawn JE, Lee AC, Kinney M, Sibley L, Carlo WA, Paul VK, et al. Two million intrapartum-related stillbirths and neonatal deaths: where, why, and what can be done?. International Journal of Gynecology and Obstetrics 2009;107 Suppl 1:S5-18, S19.
Lederman 1978
  • Lederman RP, Lederman E, Work BA Jr, McCann DS. The relationship of maternal anxiety, plasma catecholamines, and plasma cortisol to progress in labor. American Journal of Obstetrics & Gynecology 1978;132(5):495-500.
Lovold 2008
  • Lovold A, Stanton C, Armbruster D. How to avoid iatrogenic morbidity and mortality while increasing availability of oxytocin and misoprostol for PPH prevention?. International Journal of Gynecology & Obstetrics 2008;103(3):276-82.
Margulies 1992
Matonhodze 2003
  • Matonhodze B, Hofmeyr GJ, Levin J. Labour induction at term--a randomised trial comparing Foley catheter plus titrated oral misoprostol solution, titrated oral misoprostol solution alone, and dinoprostone. South African Medical Journal. Suid-Afrikaanse Tydskrif Vir Geneeskunde 2003;93(5):375-9.
McClure 2006
Nassar 2007
Neilson 2003
Norman 1991
Nystedt 2005
O'Hana 2008
  • O'Hana H P, Levy A, Rozen A, Greemberg L, Shapira Y, Sheiner E. The effect of epidural analgesia on labor progress and outcome in nulliparous women. Journal of Maternal-Fetal & Neonatal Medicine 2008;21(8):517-21.
Piper 1991
RevMan 2012 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Scholl 2012
Selin 2008
Sheiner 2002
  • Sheiner E, Levy A, Feinstein U, Hallak M, Mazor M. Risk factors and outcome of failure to progress during the first stage of labor: a population-based study. Acta Obstetricia et Gynecologica Scandinavica 2002;81(3):222-6.
Sheiner 2007
  • Sheiner E, Levy A, Katz M, Mazor M. Short stature - an independent risk factor for Caesarean delivery. European Journal of Obstetrics & Gynecology and Reproductive Biology 2005;120(2):175-8.
Shields 2007
Simpson 2003
Souza 2010
  • Souza AS, Scavuzzi A, Rodrigues DC, Oliveira RD, Feitosa FE, Amorim MM. Titrated oral solution of misoprostol for labour induction: a pilot study. Revista Brasileira de Ginecologia e Obstetricia 2010;32(5):208-13.
Stanton 2012
  • Stanton C, Koski A, Cofie P, Mirzabagi E, Grady BL, Brooke S. Uterotonic drug quality: an assessment of the potency of injectable uterotonic drugs purchased by simulated clients in three districts in Ghana. BMJ open 2012;2(3):e000431. [DOI: 10.1136/bmjopen-2011-000431]
Tang 2007
  • Tang OS, Gemzell-Danielsson K, Ho PC. Misoprostol: Pharmacokinetic profiles, effects on the uterus and side-effects. International Journal of Gynecology & Obstetrics 2007;99 Suppl 2:S160-S167.
Thaisomboon 2012
  • Thaisomboon A, Russameecharoen K, Wanitpongpan P, Phattanachindakun B, Changnoi A. Comparison of the efficacy and safety of titrated oral misoprostol and a conventional oral regimen for cervical ripening and labor induction. International Journal of Gynecology & Obstetrics 2012;116(1):13-6.
Uludag 2005
  • Uludag S, Salihoglu Saricali F, Madazli R, Cepni I. A comparison of oral and vaginal misoprostol for induction of labor. European Journal of Obstetrics, Gynecology, & Reproductive Biology 2005;122(1):57-60.
Vahratian 2004
  • Vahratian A, Zhang J, Troendle JF, Savitz DA, Siega-Riz AM. Maternal prepregnancy overweight and obesity and the pattern of labor progression in term nulliparous women. Obstetrics & Gynecology 2004;104(5 Pt 1):943-51.
Vahratian 2006
Villano 2011
  • Villano KS, Lo JY, Alexander JM, McIntire DD, Leveno KJ. A dose-finding study of oral misoprostol for labor augmentation. American Journal of Obstetrics and Gynecology 2011;204(6):560.e1-5.
Weeks 2005
Weeks 2007
Yakoob 2010
Zvandasara 2008
  • Zvandasara P, Saungweme G, Mlambo J, Chidembo W, Madzivanzira N, Mwanjira C. Induction of labour with titrated oral misoprostol suspension. A comparative study with vaginal misoprostol. Central African Journal of Medicine 2008;54(9-12):43-9.