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Plasma transfusion strategies for critically ill patients

  1. Oliver Karam1,*,
  2. Marisa Tucci2,
  3. Christophe Combescure3,
  4. Jacques Lacroix2,
  5. Peter C Rimensberger1

Editorial Group: Cochrane Injuries Group

Published Online: 28 DEC 2013

Assessed as up-to-date: 15 AUG 2013

DOI: 10.1002/14651858.CD010654.pub2

How to Cite

Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger PC. Plasma transfusion strategies for critically ill patients. Cochrane Database of Systematic Reviews 2013, Issue 12. Art. No.: CD010654. DOI: 10.1002/14651858.CD010654.pub2.

Author Information

  1. 1

    Geneva University Hospital, Pediatric Critical Care Unit, Geneva, Switzerland

  2. 2

    CHU Sainte Justine, University of Montreal, Pediatric Intensive Care Unit, Montreal, QC, Canada

  3. 3

    Geneva University Hospital, Center for Clinical Research, Geneva, Switzerland

*Oliver Karam, Pediatric Critical Care Unit, Geneva University Hospital, 6 rue Willy Donzé, Geneva, 1211, Switzerland.

Publication History

  1. Publication Status: New
  2. Published Online: 28 DEC 2013



References to studies excluded from this review

  1. References to studies excluded from this review
  2. Additional references
Müller 2011 {published data only (unpublished sought but not used)}
  • Müller MC, de Jonge E, Arbous MS, Spoelstra-de Man AM, Karakus A, Vroom MB, et al. Transfusion of fresh frozen plasma in non-bleeding ICU patients—TOPIC trial: study protocol for a randomized controlled trial. Trials 2011;12(266):1-7. [PUBMED: 22196464]

Additional references

  1. References to studies excluded from this review
  2. Additional references
Abdel-Wahab 2006
Afshari 2011
  • Afshari A, Wikkelsø A, Brok J, Møller AM, Wetterslev J. Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database of Systematic Reviews 2011, Issue 3. [DOI: 10.1002/14651858.CD007871.pub2; PUBMED: 21412912]
Bateman 2008
  • Bateman ST, Lacroix J, Boven K, Forbes P, Barton R, Thomas NJ, et al. Anemia, blood loss, and blood transfusions in North American children in the intensive care unit. American Journal of Respiratory and Critical Care Medicine 2008;178(1):26-33. [PUBMED: 18420962]
Carson 2012
Crosby 1997
  • Expert Working Group. Guidelines for red blood cell and plasma transfusion for adults and children. Canadian Medical Association Journal 1997;156(11 suppl):S1-24.
Dara 2005
  • Dara SI, Rana R, Afessa B, Moore SB, Gajic O. Fresh frozen plasma transfusion in critically ill medical patients with coagulopathy. Critical Care Medicine 2005;33(11):2667-71. [PUBMED: 16276195]
Gong 2005
  • Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC. Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Critical Care Medicine 2005;33(6):1191-8. [PUBMED: 15942330]
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
Holland 2006
  • Holland LL, Brooks JP. Toward rational fresh frozen plasma transfusion: the effect of plasma transfusion on coagulation test results. American Journal of Clinical Pathology 2006;126(1):133-9. [PUBMED: 16753596]
Hébert 1999
  • Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. New England Journal of Medicine 1999;340(6):409-17. [PUBMED: 9971864]
Karam 2013
Karam 2013a
  • Karam O, Tucci M, Lacroix J, Rimensberger PC. International survey on plasma transfusion practices in critically ill children. Transfusion. In press.
Khan 2007
  • Khan H, Belsher J, Yilmaz M, Afessa B, Winters JL, Moore SB, et al. Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 2007;131(5):1308-14. [PUBMED: 17400669]
Kneyber 2007
  • Kneyber MC, Hersi MI, Twisk JW, Markhorst DG, Plötz FB. Red blood cell transfusion in critically ill children is independently associated with increased mortality. Intensive Care Medicine 2007;33(8):1414-22. [PUBMED: 17572875]
Lacroix 2007
  • Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, et al. Transfusion strategies for patients in pediatric intensive care units. New England Journal of Medicine 2007;356(16):1609-19. [PUBMED: 17442904]
Lauzier 2007
Liumbruno 2009
  • Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G. Recommendations for the transfusion of plasma and platelets. Blood Transfusion 2009;7(2):132-50. [PUBMED: 19503635]
Luk 2002
  • Luk C, Eckert KM, Barr RM, Chin-Yee IH. Prospective audit of the use of fresh-frozen plasma, based on Canadian Medical Association transfusion guidelines. Canadian Medical Association Journal 2002;166(12):1539-40. [PUBMED: 12074120]
Narick 2012
National Survey 2009
  • Office of the Assistant Secretary for Health. The 2009 National Blood Collection and Utilization Survey Report. Washington, DC: US Department of Health and Human Services, 2011. [: 9781563953286]
O'Shaughnessy 2004
Puetz 2012
  • Puetz J, Witmer C, Huang Y, Raffini L. Widespread use of fresh frozen plasma in US children's hospitals despite limited evidence demonstrating a beneficial effect. Journal of Pediatrics 2012;160(2):210-5. [PUBMED: 21924435]
Sarani 2008
  • Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH. Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. Critical Care Medicine 2008;36(4):1114-8. [PUBMED: 18379235]
Schmidt 2012
Stanworth 2007
Stanworth 2011
  • Stanworth SJ, Walsh TS, Prescott RJ, Lee RJ, Watson DM, Wyncoll D. A national study of plasma use in critical care: clinical indications, dose and effect on prothrombin time. Critical Care 2011;15(2):R108. [PUBMED: 21466676]
van Stein 2010
Villanueva 2013
  • Villanueva C, Colomo A, Bosch A, Concepción M, Hernandez-Gea V, Aracil C, et al. Transfusion strategies for acute upper gastrointestinal bleeding. New England Journal of Medicine 2013;368(1):11-21. [PUBMED: 23281973]
Vlaar 2009
Watson 2009
  • Watson GA, Sperry JL, Rosengart MR, Minei JP, Harbrecht BG, Moore EE, et al. Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome. Journal of Trauma 2009;67(2):221-7. [PUBMED: 19667872]
Zink 2009
  • Zink KA, Sambasivan CN, Holcomb JB, Chisholm G, Schreiber MA. A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study. American Journal of Surgery 2009;197(5):565-70. [PUBMED: 19393349]