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Micronutrient supplementation for children with HIV infection

  1. James H Irlam1,*,
  2. Nandi Siegfried2,
  3. Marianne E Visser3,
  4. Nigel C Rollins4,5

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 11 OCT 2013

Assessed as up-to-date: 27 NOV 2011

DOI: 10.1002/14651858.CD010666


How to Cite

Irlam JH, Siegfried N, Visser ME, Rollins NC. Micronutrient supplementation for children with HIV infection. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD010666. DOI: 10.1002/14651858.CD010666.

Author Information

  1. 1

    University of Cape Town, Primary Health Care Directorate, Cape Town, Western Cape, South Africa

  2. 2

    University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa

  3. 3

    Cape town, South Africa

  4. 4

    World Health Organization, Department of Maternal, Newborn, Child and Adolescent Health (MCA), 1211 Geneva 27, Switzerland

  5. 5

    University of Kwazulu-Natal, Department of Paediatrics and Child Health, Durban, South Africa

*James H Irlam, Primary Health Care Directorate, University of Cape Town, E47 OMB, Groote Schuur Hospital, Cape Town, Western Cape, 7925, South Africa. James.Irlam@uct.ac.za.

Publication History

  1. Publication Status: New
  2. Published Online: 11 OCT 2013

SEARCH

[Figure 1]
Figure 1. Results of search of PubMed, EMBASE, and CENTRAL from Jan. 2010 to July 2011 (RCTs in child populations only)
[Figure 2]
Figure 2. Risk of bias summary: review of authors' judgements about risk of bias in each included study
[Figure 3]
Figure 3. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 4]
Figure 4. Meta-analysis of mortality in Vitamin A trials
[Analysis 1.1]
Analysis 1.1. Comparison 1 Vitamin A, Outcome 1 All-cause mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Vitamin A, Outcome 2 Child growth at 12 months.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Vitamin D, Outcome 1 CD4 counts at 12 months.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Vitamin D, Outcome 2 Viral load at 12 months.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Zinc, Outcome 1 Viral load at 9 months.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Zinc, Outcome 2 Mortality at 9 months.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Zinc, Outcome 3 CD4 % at 9 months.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Zinc, Outcome 4 Clinic visits.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Zinc, Outcome 5 Diarrhoea incidence in HIV+ children with at least one follow-up visit.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Multiple micronutrients, Outcome 1 Mortality at 12 months.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Multiple micronutrients, Outcome 2 CD4 count.
[Analysis 4.3]
Analysis 4.3. Comparison 4 Multiple micronutrients, Outcome 3 Duration of hospitalisation.
[Analysis 4.4]
Analysis 4.4. Comparison 4 Multiple micronutrients, Outcome 4 Change in appetite at 6 months.
[Analysis 4.5]
Analysis 4.5. Comparison 4 Multiple micronutrients, Outcome 5 Anthropometric Z scores.