Intervention Review

You have free access to this content

Micronutrient supplementation for children with HIV infection

  1. James H Irlam1,*,
  2. Nandi Siegfried2,
  3. Marianne E Visser3,
  4. Nigel C Rollins4,5

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 11 OCT 2013

Assessed as up-to-date: 27 NOV 2011

DOI: 10.1002/14651858.CD010666


How to Cite

Irlam JH, Siegfried N, Visser ME, Rollins NC. Micronutrient supplementation for children with HIV infection. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD010666. DOI: 10.1002/14651858.CD010666.

Author Information

  1. 1

    University of Cape Town, Primary Health Care Directorate, Cape Town, Western Cape, South Africa

  2. 2

    University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa

  3. 3

    Cape town, South Africa

  4. 4

    World Health Organization, Department of Maternal, Newborn, Child and Adolescent Health (MCA), 1211 Geneva 27, Switzerland

  5. 5

    University of Kwazulu-Natal, Department of Paediatrics and Child Health, Durban, South Africa

*James H Irlam, Primary Health Care Directorate, University of Cape Town, E47 OMB, Groote Schuur Hospital, Cape Town, Western Cape, 7925, South Africa. James.Irlam@uct.ac.za.

Publication History

  1. Publication Status: New
  2. Published Online: 11 OCT 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Arpadi 2009 {published data only}
  • Arpadi SM, McMahon D, Abrams EJ, Bamji M, Purswani M, Engelson ESetal. Effect of bimonthly supplementation with oral cholecalciferol on serum 25-hydroxyvitamin D concentrations in HIV-infected children and adolescents. Pediatrics 2009;123(1):e121-6.
Bobat 2005 {published data only}
  • Bobat, R, Coovadia, H, Stephen, C, et al. Safety and efficacy of zinc supplementation for children with HIV-1 infection in South Africa: A randomised double-blind placebo-controlled trial. Lancet 2005;366(9500):1862-7.
Coutsoudis 1995 {published data only}
  • Coutsoudis A, Bobat RA, Coovadia HM, Kuhn L, Tsai WY, Stein ZA. The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. American Journal of Public Health 1995;85(8):1076-81.
Fawzi 1999 {published data only}
  • Fawzi WW, Mbise R, Hertzmark E, Fataki MR, Herrera MG, Ndossi G, et al. A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania. The Pediatric Infectious Disease Journal 1999;18(2):127-33.
  • Fawzi WW, Mbise R, Spiegelman D, Fataki M, Hertzmark E, Ndossi G. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. The Journal of Pediatrics 2000;137(5):660-7.
  • Villamor E, Mbise R, Spiegelman D, Hertzmark E, Fataki M, Peterson KE, et al. Vitamin A supplements ameliorate the adverse effect of HIV-1, malaria, and diarrheal infections on child growth. Pediatrics 2002;109(1 (E6)):1-10.
Hanekom 2000 {published data only}
  • Hanekom WA, Yogev R, Heald LM, Edwards KM, Hussey GD, Chadwick EG. Effect of vitamin A therapy on serologic responses and viral load changes after influenza vaccination in children infected with the human immunodeficiency virus. The Journal of Pediatrics 2000;36(4):550-2.
Hussey 1996 {published data only}
  • Hussey G, Hughes J, Potgieter S, Kessow G, Burgess J, Beatty Detal. Vitamin A status and supplementation and its effect on immunity in children with AIDS. XVII International Vitamin A Consultative Group (IVACG) Meeting, Guatemala City. 1996:81.
Luabeya 2007 {published data only}
  • Chhagan MK, Van den Broeck J, Luabeya KK, Mpontshane N, Tomkins A, Bennish ML. Effect on longitudinal growth and anemia of zinc or multiple micronutrients added to vitamin A: a randomized controlled trial in children aged 6-24 months. BMC public health 2010;10:145. [PUBMED: 20298571]
  • Chhagan MK, Van den Broeck J, Lubaeya KK, Mpontshane N, Tucker KL, Bennish ML. Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa. European journal of clinical nutrition 2009;63(7):850-7.
  • Luabeya, K. K, Mpontshane, N, Mackay, M, et al. Zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in South African children: A randomized controlled trial. PLoS ONE 2007;2(6):e541.
Mda 2010a {published data only}
  • Mda S, van Raaij JM, de Villiers FP, MacIntyre UE, Kok FJ. Short-term micronutrient supplementation reduces the duration of pneumonia and diarrheal episodes in HIV-infected children. The Journal of nutrition 2010;140(5):969-74. [PUBMED: 20335632]
Mda 2010b {published data only}
  • Mda S, van Raaij JM, Macintyre UE, de Villiers FP, Kok FJ. Improved appetite after multi-micronutrient supplementation for six months in HIV-infected South African children. Appetite 2010;54(1):150-5. [PUBMED: 19815042]
Ndeezi 2010 {published data only}
  • Ndeezi G, Tylleskar T, Ndugwa CM, Tumwine JK. Effect of multiple micronutrient supplementation on survival of HIV-infected children in Uganda: a randomized, controlled trial. Journal of the International AIDS Society 2010;13:18. [PUBMED: 20525230]
Semba 2005 {published data only}
  • Semba RD, Ndugwa C, Perry RT, Clark TD, Jackson JB, Melikian Getal. Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus-infected children in Uganda: A controlled clinical trial. Nutrition 2005;21(1):25-31.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chatterjee 2010 {published data only}
  • Chatterjee A, Bosch RJ, Hunter DJ, Manji K, Msamanga GI, Fawzi WW. Vitamin A and vitamin B-12 concentrations in relation to mortality and morbidity among children born to HIV-infected women. Journal of tropical pediatrics 2010;56(1):27-35. [PUBMED: 19502599]
CIGNIS 2010 {published data only}
  • Chilenje Infant Growth, Nutrition and Infection (CIGNIS) Study Team. Micronutrient fortification to improve growth and health of maternally HIV-unexposed and exposed Zambian infants: a randomised controlled trial. PloS one 2010;5(6):e11165. [PUBMED: 20567511]
  • Filteau S, Baisley K, Chisenga M, Kasonka L, Gibson RS. Provision of micronutrient-fortified food from 6 months of age does not permit HIV-exposed uninfected Zambian children to catch up in growth to HIV-unexposed children: a randomized controlled trial. Journal of acquired immune deficiency syndromes (1999) 2011;56(2):166-75. [PUBMED: 21119523]

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Aggarwal 2007
  • Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: a meta-analysis. Pediatrics 2007;119(6):1120-30. [PUBMED: 17545379]
ASSaf 2007
  • Irlam J, Hussey G, Dhansay M. The effects of nutritional interventions in HIV/AIDS: Micronutrients. In: Assaf Study Panel, editor(s). HIV/AIDS, TB and Nutrition: Scientific inquiry into the nutritional influences on human immunity with special reference to HIV infection and active TB in South Africa. Pretoria: Academy of Science of South Africa, 2007:143-51.
Baeten 1993
  • Beaton G, Martorell R, Aronson KJ, Edmonston B, McCabe G, Ross AC, Harvey B. Effectiveness of vitamin A supplementation in the control of young child morbidity and mortality in developing countries. ACC/SCN State of the Art Series, Nutrition Policy Paper No 13 1993.
Baqui 2002
  • Baqui AH, Black RE, El Arifeen S, Yunus M, Chakraborty J, Ahmed S, et al. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. British Medical Journal 2002;325(7372):1059.
Bhandari 2002
  • Bhandari N, Bahl R, Taneja S, Strand T, Molbak K, Ulvik RJ, et al. Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children. Pediatrics June 2002;109(6):e86.
Bhutta 1999
  • Bhutta ZA, Black RE, Brown KH, Gardner JM, Gore S, Hidayat A, et al. Prevention of diarrhea and pneumonia by zinc supplementation in children in developing countries: pooled analysis of randomized controlled trials. Zinc Investigators' Collaborative Group. The Journal of pediatrics 1999;135(6):689-97. [PUBMED: 10586170]
Bhutta 2000
  • Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled trials. The American journal of clinical nutrition 2000;72(6):1516-22. [PUBMED: 11101480]
Black 2010
  • Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I,   Bassani DG, et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 2010;375(9730):1969-87. [PUBMED: 20466419]
Filteau 2001
  • Filteau SM, Rollins NC, Coutsoudis A, Sullivan KR, Willumsen JF, Tomkins AM. The effect of antenatal vitamin A and beta-carotene supplementation on gut integrity of infants of HIV-infected South African women. Journal of pediatric gastroenterology and nutrition 2001;32(4):464-70. [PUBMED: 11396815]
GradePro 2008
  • Jan Bozek, Andrew Oxman, Olger Schunemann. Gradepro. 3.2.2 for Windows. GRADE Working Group, 2008.
Haider 2008
  • Haider B, Bhutta Z. Review of vitamin A supplementation in the neonatal period. Web appendix to Bhutta et al, 2008. Available at: http://www.globalnutritionseries.org/web_appendices (accessed on 24.09.2008) 2008.
Horton 2008
  • Horton S, Begin  F, Greig  A, Lakshman A. Copenhagen Consensus best practices paper on Micronutrient supplements for child survival (Vitamin A and Zinc). Copenhagen Consensus Center Working Paper 2008.
Micronutrient Initiative 2009
  • The Micronutrient Initiative. Investing in the Future: A United Call to Action on Vitamin and Mineral Deficiencies. http://www.unitedcalltoaction.org/flashreport.asp (accesssed 8 June 2010) 2009.
Piwoz 2000
  • Piwoz EG, Preble EA. HIV/AIDS and Nutrition: A Review of the Literature and recommendations for Nutritional Care and Support in sub-Saharan Africa. Refugee Studies Centre. Washington: Support for Analysis and Research in Africa (SARA) Project, Academy for Educational Development, 2000.
Robberstad 2004
  • Robberstad B, Strand T, Black RE, Sommerfelt H. Cost-effectiveness of zinc as adjunct therapy foracute childhood diarrhea in developing countries. WHO Bulletin 2004;82(7):523-31.
Strand 2002
  • Strand TA, Chandyo RK, Bahl R, Sharma PR, Adhikari RK, Bhandari N, et al. Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. Pediatrics 2002;109(5):898-903.
UNAIDS 2010
  • UNAIDS. UNAIDS Report on the Global AIDS Epidemic 2010. http://www.unaids.org/globalreport/ Accessed 14 Novemeber 2011.
UNICEF 2007
  • UNICEF. Vitamin A Supplementation - A decade of progress. UNICEF report 2007.
UNICEF 2009
  • UNICEF. Tracking Progress on Child and Maternal Nutrition: A survival and development priority. New York: UNICEF Division of Communication, November 2009. [: ISBN 978-92-806-4482-1]
Wagstaff 2004
  • Wagstaff A, Cleason M. The Millennium Development Goals for health: rising to the challenges. Washington DC: World Bank 2004.
WHO 2003
  • World Health Organisation. WHO Technical Consultation on Nutrient Requirements for People Living with HIV/AIDS. Nutrient Requirements for People Living with HIV/AIDS. Geneva: World Health Organisation, 2003.
WHO 2009
  • World Health Organization. Handbook IMCI Integrated Management of Childhood Illness for High HIV Settings. Geneva: World Health Organization, 2009.
WHO/UNICEF 2004
  • WHO/UNICEF. Clinical Management of Acute Diarrhea. WHO/UNICEF Joint Statement 2004.
Zinc Investigators Collaborative Group 2000
  • Zinc Investigators Collaborative Group. Therapeutic effects of oral zinc in acute and persistent diarrhoea in children in developing countries: Pooled analysis of randomized controlled trials. Am J Clin Nutr 2000;72:1516-22.

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Irlam 2010