Diagnostic Test Accuracy Protocol

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Transcranial Doppler sonography for detecting stenosis or occlusion of intracranial arteries in people with acute ischaemic stroke

  1. Alessia Mattioni1,*,
  2. Miriam Brazzelli2,
  3. Silvia Cenciarelli1,
  4. Tatiana Mazzoli1,
  5. Massimo Del Sette3,
  6. Carlo Gandolfo3,
  7. Marinella Marinoni4,
  8. Cinzia Finocchi3,
  9. Valentina Saia4,
  10. Paolo Eusebi5,
  11. Peter AG Sandercock2,
  12. Stefano Ricci1

Editorial Group: Cochrane Stroke Group

Published Online: 5 SEP 2013

Assessed as up-to-date: 1 JUL 2013

DOI: 10.1002/14651858.CD010722


How to Cite

Mattioni A, Brazzelli M, Cenciarelli S, Mazzoli T, Del Sette M, Gandolfo C, Marinoni M, Finocchi C, Saia V, Eusebi P, Sandercock PAG, Ricci S. Transcranial Doppler sonography for detecting stenosis or occlusion of intracranial arteries in people with acute ischaemic stroke (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 9. Art. No.: CD010722. DOI: 10.1002/14651858.CD010722.

Author Information

  1. 1

    ASL 1 dell' Umbria, UO Neurologia, Città di Castello, Perugia, Italy

  2. 2

    University of Edinburgh, Division of Clinical Neurosciences, Edinburgh, UK

  3. 3

    Università di Genova, Dipartimento Neuroscienze, Oftalmologia e Genetica, Genova, Italy

  4. 4

    University of Florence, Department of Neurosciences, Florence, Italy

  5. 5

    Regional Health Authority of Umbria, Epidemiology Department, Perugia, Umbria, Italy

*Alessia Mattioni, UO Neurologia, ASL 1 dell' Umbria, Via Luigi Angelini 10, Città di Castello, Perugia, 06012, Italy. alessia.mattioni@asl1.umbria.it. alessiamattioni@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 5 SEP 2013

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Table 1. Risk of bias and applicability judgements for the quality assessment of diagnostic accuracy studies (QUADAS-2)

DomainPatient selectionIndex testReference standardFlow and timing

DescriptionDescribe methods of patient
selection
Describe included patients (previous testing, presentation, intended use of index
test, and setting)
Describe the index test and how it was conducted
and interpreted
Describe the reference standard and how it was conducted and interpretedDescribe any patients who did not receive the index tests or reference standard or who were excluded from the 2 x 2 table (refer to flow diagram)
Describe the interval and any interventions between index tests and the reference standard

Signalling question (yes, no, or unclear)Was a consecutive or random sample of patients enrolled?
Was a case-control design avoided?
Did the study avoid inappropriate exclusions?
Were the index test results interpreted without knowledge of the results of the reference standard? If a threshold was used, was it prespecified?Is the reference standard likely to correctly classify the target condition?
Were the reference standard results interpreted without knowledge of the results of the index test?
Was there an appropriate interval between index
tests and reference standard?
Did all patients receive a reference standard?
Did all patients receive the same reference standard?
Were all patients included in the analysis?

Risk of bias (high, low, or unclear)Could the selection of patients have introduced bias?Could the conduct or interpretation of the index test have introduced bias?Could the reference standard, its conduct, or its interpretation have introduced bias?Could the patient flow have introduced bias?

Concerns about applicability (high, low, or unclear)Are there concerns that the included patients do not match the review question?Are there concerns that the index test, its conduct, or its interpretation differ from the review question?Are there concerns that the target condition as defined by the reference standard does not match the review question?