Mini-Mental State Examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI)

  • Protocol
  • Diagnostic

Authors

  • Ingrid Arevalo-Rodriguez,

    Corresponding author
    1. Fundación Universitaria de Ciencias de la Salud, Hospital de San José/Hospital Infantil de San José, Division of Research, Bogotá D.C., Colombia
    • Ingrid Arevalo-Rodriguez, Division of Research, Fundación Universitaria de Ciencias de la Salud, Hospital de San José/Hospital Infantil de San José, Bogotá D.C., 11001, Colombia. inarev7@yahoo.com. iarevalo@fucsalud.edu.co.

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  • Nadja Smailagic,

    1. University of Cambridge, Institute of Public Health, Cambridge, UK
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  • Agustín Ciapponi,

    1. Southern American Branch of the Iberoamerican Cochrane Centre, Argentine Cochrane Centre IECS, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Capital Federal, Argentina
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  • Erick Sanchez-Perez,

    1. Hospital Infantil Universitario de San José-FUCS, Neurosciences, Bogotá, Colombia
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  • Antri Giannakou,

    1. Bristol University, School of Social and Community Medicine, Bristol, UK
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  • Marta Roqué i Figuls,

    1. CIBER Epidemiología y Salud Pública (CIBERESP), Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Catalunya, Spain
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  • Olga L Pedraza,

    1. Hospital Infantil Universitario de San José-FUCS, Neurosciences, Bogotá, Colombia
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  • Xavier Bonfill Cosp,

    1. CIBER Epidemiología y Salud Pública (CIBERESP), Spain - Universitat Autònoma de Barcelona, Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Catalonia, Spain
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  • Sarah Cullum

    1. Bristol University, Centre for Mental Health, Addiction and Suicide Research, School of Community Medicine, Bristol, UK
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Abstract

This is a protocol for a Cochrane Review (Diagnostic test accuracy). The objectives are as follows:

To determine the diagnostic accuracy of the MMSE at various thresholds for detecting individuals with MCI at baseline who would clinically convert to Alzheimer’s disease dementia or other forms of dementia at follow-up

To assess the heterogeneity of test accuracy by population (e.g. memory clinics, community settings) and MMSE thresholds, amongst other factors.