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Vitamin E supplementation for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack

  1. Malinee Neelamegam1,*,
  2. Irene Looi2,
  3. Kee Sing Ng3,
  4. Sharad Suryakant Malavade1

Editorial Group: Cochrane Stroke Group

Published Online: 22 OCT 2013

Assessed as up-to-date: 11 OCT 2013

DOI: 10.1002/14651858.CD010797


How to Cite

Neelamegam M, Looi I, Ng KS, Malavade SS. Vitamin E supplementation for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD010797. DOI: 10.1002/14651858.CD010797.

Author Information

  1. 1

    University of South Florida, College of Public Health, Tampa, Florida, USA

  2. 2

    Hospital Seberang Jaya, Department of Medicine, Seberang Jaya, Malaysia

  3. 3

    Hospital Pulau Pinang, Department of Internal Medicine, Georgetown, Malaysia

*Malinee Neelamegam, College of Public Health, University of South Florida, 13201 Bruce B. Downs Blvd, MDC-056, Tampa, Florida, 33612, USA. nmalinee.79@gmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 22 OCT 2013

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Table 1. Comparison between tocopherols and tocotrienols

TocopherolsTocotrienols

1. 4 isomers - alpha, beta, gamma and delta1. 4 isomers - alpha, beta, gamma and delta

2. Fat soluble antioxidant2. Fat soluble antioxidant that is more potent than tocopherols due to its chemical structure (Yoshida 2003)

3. Absence of three double bonds in side chain3. Presence of three double bonds in side chain. This unsaturated side chain provides its unique properties of better penetration into tissues with saturated fatty layers (Suzuki 1993; Schaffer 2005)

4. Lack of data to support its role in the protection of brain cell damage, and reduction of cholesterol, cardiovascular diseases and cancer4. Can potentially protect brain cell damage (Sen 2006) and reduce cholesterol (Parker 1993), cardiovascular diseases (Pruthi 2001) and cancer (Inokuchi 2003)

5. α-Tocopherols interfere with the absorption of tocotrienols, increase tocotrienols catabolism (Sontag 2007) and its clinical benefits in cholesterol reduction (Qureshi 1996; Stocker 2004)