Diagnostic Test Accuracy Protocol

CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)

  1. Craig Ritchie1,*,
  2. Nadja Smailagic2,
  3. Emma C Ladds3,
  4. Anna H Noel-Storr4,
  5. Obioha Ukoumunne5,
  6. Steven Martin2

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 26 OCT 2013

DOI: 10.1002/14651858.CD010803


How to Cite

Ritchie C, Smailagic N, Ladds EC, Noel-Storr AH, Ukoumunne O, Martin S. CSF tau and the CSF tau/ABeta ratio for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI) (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD010803. DOI: 10.1002/14651858.CD010803.

Author Information

  1. 1

    Imperial College London, London, UK

  2. 2

    University of Cambridge, Institute of Public Health, Cambridge, UK

  3. 3

    John Radcliffe Hospital, Oxford University Medical School, Oxford, UK

  4. 4

    University of Oxford, Radcliffe Department of Medicine, Oxford, UK

  5. 5

    University of Exeter Medical School, University of Exeter, Peninsula CLAHRC, Exeter, Devon, UK

*Craig Ritchie, Imperial College London, London, UK. c.ritchie@imperial.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 26 OCT 2013

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine the diagnostic accuracy of 1) CSF tau, 2) CSF p-tau, 3) the CSF tau/ABeta ratio and 4) the CSF p-tau/ABeta ratio index tests at various thresholds for detecting participants with mild cognitive impairment (MCI) at baseline who would clinically convert to Alzheimer’s disease or other forms of dementia at follow-up.

To investigate the amount of and associations of heterogeneity in the included studies of test accuracy.

We expect that heterogeneity will be likely and that it will be an important component of the review. The potential sources of heterogeneity, which will be used as a framework for the investigation of heterogeneity, include target population, index test, target disorder and study quality.