Intervention Protocol

You have free access to this content

Intravenous hyoscine-N-butyl bromide for aiding colonoscopy

  1. Steven R Brown1,
  2. Wal Baraza2,*

Editorial Group: Cochrane Colorectal Cancer Group

Published Online: 29 OCT 2013

DOI: 10.1002/14651858.CD010809

How to Cite

Brown SR, Baraza W. Intravenous hyoscine-N-butyl bromide for aiding colonoscopy (Protocol). Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD010809. DOI: 10.1002/14651858.CD010809.

Author Information

  1. 1

    Sheffield Teaching Hospitals, Surgery, Sheffield S7, South Yorkshire, UK

  2. 2

    NHS, Colorectal Surgery, Sheffield, Yorkshire, UK

*Wal Baraza, Colorectal Surgery, NHS, 59 Ryegate Road Sheffield, Sheffield, Yorkshire, S10 5FB, UK.

Publication History

  1. Publication Status: New
  2. Published Online: 29 OCT 2013



Additional references

Ai 2006
  • Ai M, Yamaguchi T, Odaka T, Mitsuhashi K, Shishido T, Yan J, et al. Objective assessment of the antispasmodic effect of shakuyaku-kanzo-to (TJ-68), a Chinese herbal medicine, on the colonic wall by direct spraying during colonoscopy. World Journal of Gastroenterology 2006;12(5):760-4.
Cotton 2008
  • Cotton PB, Williams CB, Hawes RH, Saunders BP. Practical Gastrointestinal Endoscopy: The Fundamentals. 6th Edition. Wiley-Blackwell, 2008.
de Brouwer 2012
  • de Brouwer EJ, Arbouw ME, van der Zwet WC, van Herwaarden MA, Ledeboer M, Jansman FG, et al. Hyoscine N-butylbromide does not improve polyp detection during colonoscopy: a double-blind, randomized, placebo-controlled, clinical trial. Gastrointestinal Endoscopy 2012;75(4):835-40.
Elphick 2009
  • Elphick DA, Donnelly MT, Smith KS, Riley SA. Factors associated with abdominal discomfort during colonoscopy: a prospective analysis. European Journal of Gastroenterology and Hepatology 2009;21(9):1076-82.
Goei 2000
  • Goei R, Kessels AH, Nix M, Knipschild PG. Randomised clinical trial on the use of antispasmodic drugs in barium enema: impact on radiological practice. European Journal of Radiology 2000;36(1):32-5.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Hull 1994
Lee 2009
  • Lee H, Kim JJ, Min BH, Lee JH, Kim YH, Chang DK, et al. Effectiveness of warm water consumption to reduce patient discomfort during colonoscopy: a randomized controlled trial. American Journal of Gastroenterology 2009;104(12):2935-41.
Lee 2010
  • Lee JM, Cheon JH, Park JJ, Moon CM, Kim ES, Kim TI, et al. Effects of Hyosine N-butyl bromide on the detection of polyps during colonoscopy. Hepatogastroenterology 2010;57(97):90-4.
Morson 1971
Mui 2004
  • Mui LM, Ng EK, Chan KC, Ng CS, Yeung AC, Chan SK, et al. Randomised, double-blinded, placebo-controlled trial of intravenously administered hyoscine N-butyl bromide in patients undergoing colonoscopy with patient controlled sedation. Gastrointestinal Endoscopy 2004;59(1):22-7.
Review Manager 2013 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2013.
Saunders 1996
Shah 2002
Takahashi 2005
  • Takahashi Y, Tanaka H, Kinjo M, Sakumoto K. Prospective evaluation of factors predicting difficulty and pain during sedation-free colonoscopy. Diseases of the Colon and Rectum 2005;48(6):1295-300.
Yoong 2004
Yoshikawa 2006
  • Yoshikawa I, Yamasaki M, Taguchi M, Kanda K, Tashiro M, Kume K, et al. Comparison of glucagon and scopolamine butylbromide as premedication for colonoscopy in unsedated patients. Diseases of the Colon and Rectum 2006;49(9):1393-8.