Diagnostic Test Accuracy Protocol

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Duplex ultrasound for the diagnosis of symptomatic deep vein thrombosis in the lower limb

  1. Francesca M Chappell1,
  2. Fay Crawford2,*,
  3. Alina Andras3,
  4. Steve Goodacre4,
  5. James E McCaslin3,
  6. Karen Welch5,
  7. Crispian Oates6

Editorial Group: Cochrane Vascular Group

Published Online: 20 JAN 2014

DOI: 10.1002/14651858.CD010930

How to Cite

Chappell FM, Crawford F, Andras A, Goodacre S, McCaslin JE, Welch K, Oates C. Duplex ultrasound for the diagnosis of symptomatic deep vein thrombosis in the lower limb (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD010930. DOI: 10.1002/14651858.CD010930.

Author Information

  1. 1

    University of Edinburgh, Division of Clinical Neurosciences, Edinburgh, UK

  2. 2

    Freeman Hospital, Department of Vascular Surgery, Newcastle upon Tyne, UK

  3. 3

    Freeman Hospital, Northern Vascular Centre, Newcastle upon Tyne, UK

  4. 4

    The University of Sheffield, Medical Care Research Unit, Sheffield, UK

  5. 5

    University of Edinburgh, Public Health Sciences, Edinburgh, UK

  6. 6

    Newcastle upon Tyne Hospital Trust, Radiology, Newcastle upon Tyne, UK

*Fay Crawford, Department of Vascular Surgery, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. fay.crawford@nuth.nhs.uk. fay.crawford@ed.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 20 JAN 2014




  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To estimate the sensitivity and specificity of duplex ultrasound for the detection of distal and proximal DVT in symptomatic patients with prior testing by a clinical prediction rule (with or without additional D-dimer testing).

The accuracy of ultrasound for DVT may be affected by body mass index and whether the patient has had a previous DVT. If possible, we shall investigate both previous DVT and body mass index as possible sources of heterogeneity, but recognise that these are patient-specific rather than study-specific characteristics. This means that results reported at the study level, for example average body mass index, may not be informative in an analysis and are more appropriately investigated with individual patient data. However, such an analysis may be possible if studies report results stratified by previous DVT status or body mass index. Two study-specific characteristics we shall investigate are the generation of the technology of the ultrasound scanner and type of reference standard: ascending venography, CT venography, or MR venography. Moreover, as the accuracy of duplex ultrasound depends on whether the DVT is distal or proximal, we shall perform separate meta-analyses according to site.