Intervention Review

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Levetiracetam for neuropathic pain in adults

  1. Philip J Wiffen1,
  2. Sheena Derry1,*,
  3. R Andrew Moore1,
  4. Michael PT Lunn2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 7 JUL 2014

DOI: 10.1002/14651858.CD010943.pub2


How to Cite

Wiffen PJ, Derry S, Moore RA, Lunn MPT. Levetiracetam for neuropathic pain in adults. Cochrane Database of Systematic Reviews 2014, Issue 7. Art. No.: CD010943. DOI: 10.1002/14651858.CD010943.pub2.

Author Information

  1. 1

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

  2. 2

    National Hospital for Neurology and Neurosurgery, Department of Neurology and MRC Centre for Neuromuscular Diseases, London, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. sheena.derry@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 7 JUL 2014

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Levetiriacetam versus placebo, outcome: 1.1 Participants with substantial pain relief (≥50% pain intensity reduction, or complete or good pain relief).
[Figure 5]
Figure 5. Forest plot of comparison: 1 Levetiriacetam versus placebo, outcome: 1.4 Adverse event withdrawal.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Levetiriacetam versus placebo, Outcome 1 Participants with substantial pain relief (≥50% pain intensity reduction, or complete or good pain relief).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Levetiriacetam versus placebo, Outcome 2 Participants with at least one adverse event.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Levetiriacetam versus placebo, Outcome 3 All cause withdrawal.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Levetiriacetam versus placebo, Outcome 4 Adverse event withdrawal.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Levetiriacetam versus placebo, Outcome 5 Lack of efficacy withdrawal.