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Plasma and Cerebrospinal fluid (CSF) Abeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting

  1. Michelle Kokkinou1,
  2. Nadja Smailagic2,
  3. Anna H Noel-Storr3,
  4. Chris Hyde4,
  5. Obioha Ukoumunne5,
  6. Rosie E Worrall6,
  7. Anja Hayen7,
  8. Meera Desai8,
  9. Craig Ritchie1,*

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 31 JAN 2014

DOI: 10.1002/14651858.CD010945


How to Cite

Kokkinou M, Smailagic N, Noel-Storr AH, Hyde C, Ukoumunne O, Worrall RE, Hayen A, Desai M, Ritchie C. Plasma and Cerebrospinal fluid (CSF) Abeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD010945. DOI: 10.1002/14651858.CD010945.

Author Information

  1. 1

    Imperial College London, London, UK

  2. 2

    University of Cambridge, Institute of Public Health, Cambridge, UK

  3. 3

    University of Oxford, Radcliffe Department of Medicine, Oxford, UK

  4. 4

    University of Exeter Medical School, University of Exeter, Peninsula Technology Assessment Group (PenTAG), Exeter, UK

  5. 5

    University of Exeter Medical School, University of Exeter, Peninsula CLAHRC, Exeter, Devon, UK

  6. 6

    Oxford University Medical School, Oxford, UK

  7. 7

    University of Oxford, John Radcliffe Hospital, Nuffield Department of Clinical Neurosciences, Oxford, UK

  8. 8

    University of Oxford, Department of Experimental Psychology, Oxford, Oxfordshire, UK

*Craig Ritchie, Imperial College London, London, UK. c.ritchie@imperial.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 31 JAN 2014

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Table 1. A series of two by two tables constructed by the first column and each of the subsequent columns, cross-relating index test results (rows) with the reference standards (columns)

 Reference standard (diagnostic criteria for Alzheimer's disease dementia) information

ADD presentFTD

(ADD absent)
VD

(ADD absent)
DLB

(ADD absent)
PDD

(ADD absent)
CJD

(ADD absent)
DARCD

(ADD absent)
NPH

(ADD absent)

Index test positiveTPFPFPFPFPFPFPFP

Index test negativeFNTNTNTNTNTNTNTN

 ADD = Alzheimer's disease dementia; FTD = Frontotemporal dementia; DLB=Dementia with Lewy bodies; PDD= Parkinson's disease dementia; CJD = Creutzfeld Jacob disease; DARCD = Dementia alcohol related cognitive decline; NPH=Normal pressure hydrocephalus; TP= true positive; FP=false positive; TN= true negative; FN=false negative