Diagnostic Test Accuracy Protocol
APOE-ε4 allele for the diagnosis of Alzheimer's and other dementia disorders in people with mild cognitive impairment in a primary care setting
Editorial Group: Cochrane Dementia and Cognitive Improvement Group
Published Online: 31 JAN 2014
Assessed as up-to-date: 27 JAN 2014
Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
How to Cite
Elias-Sonnenschein LS, Viechtbauer W, Ramakers I, Ukoumunne O, Verhey FRJ, Visser PJ. APOE-ε4 allele for the diagnosis of Alzheimer's and other dementia disorders in people with mild cognitive impairment in a primary care setting (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD010949. DOI: 10.1002/14651858.CD010949.
- Publication Status: New
- Published Online: 31 JAN 2014
This is the protocol for a review and there is no abstract. The objectives are as follows:
Our primary objective is to determine the diagnostic accuracy of the APOE-ε4 allele in detecting AD dementia and other types of dementia in people with MCI in a primary care setting.
Our secondary objective is to investigate the following potential sources of heterogeneity of test accuracy, where reported:
- characteristics of participants, namely, baseline MMSE score, age, and gender;
- APOE-ε4 background prevalence;
- MCI definition;
- length of follow-up; and
- reference standards.