APOE-ε4 allele for the diagnosis of Alzheimer's and other dementia disorders in people with mild cognitive impairment in a primary care setting

  • Protocol
  • Diagnostic

Authors

  • Lyzel S Elias-Sonnenschein,

    Corresponding author
    1. Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, Netherlands
    • Lyzel S Elias-Sonnenschein, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Postbus 616, Maastricht, 6200 MD, Netherlands. lyzel.elias@yahoo.nl.

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  • Wolfgang Viechtbauer,

    1. Maastricht University, Department of Psychiatry and Neuropsychology, Maastricht, Netherlands
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  • Inez Ramakers,

    1. Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, Netherlands
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  • Obioha Ukoumunne,

    1. University of Exeter Medical School, University of Exeter, Peninsula CLAHRC, Exeter, Devon, UK
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  • Frans RJ Verhey,

    1. Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, Netherlands
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  • Pieter Jelle Visser

    1. Maastricht University, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht, Netherlands
    2. VU University Medical Centre, Department of Neurology, Amsterdam, Netherlands
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Our primary objective is to determine the diagnostic accuracy of the APOE-ε4 allele in detecting AD dementia and other types of dementia in people with MCI in a primary care setting.

Our secondary objective is to investigate the following potential sources of heterogeneity of test accuracy, where reported:

  • characteristics of participants, namely, baseline MMSE score, age, and gender;

  • APOE-ε4 background prevalence;

  • MCI definition;

  • length of follow-up; and

  • reference standards.