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Topical lidocaine for neuropathic pain in adults

  1. Sheena Derry1,*,
  2. Philip J Wiffen1,
  3. R Andrew Moore1,
  4. Jane Quinlan2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 24 JUL 2014

Assessed as up-to-date: 1 JUL 2014

DOI: 10.1002/14651858.CD010958.pub2


How to Cite

Derry S, Wiffen PJ, Moore RA, Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database of Systematic Reviews 2014, Issue 7. Art. No.: CD010958. DOI: 10.1002/14651858.CD010958.pub2.

Author Information

  1. 1

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

  2. 2

    Oxford University Hospitals Trust, Nuffield Department of Anaesthetics, Oxford, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. sheena.derry@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 24 JUL 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Binder 2009 {published data only}
Bischoff 2013 {published data only}
Cheville 2009 {published data only}
  • Cheville AL, Sloan JA, Northfelt DW, Jillella AP, Wong GY, Bearden Iii JD, et al. Use of a lidocaine patch in the management of postsurgical neuropathic pain in patients with cancer: a phase III double-blind crossover study (N01CB). Supportive Care in Cancer 2009;17(4):451-60. [DOI: 10.1007/s00520-008-0542-x]
Galer 1999 {published data only}
Galer 2002 {published data only}
  • Galer BS, Jensen MP, Ma T, Davies PS, Rowbotham MC. The lidocaine patch 5% effectively treats all neuropathic pain qualities: results of a randomized, double-blind, vehicle-controlled, 3-week efficacy study with use of the neuropathic pain scale. Clinical Journal of Pain 2002;18(5):297-301.
  • Rowbotham MC, Davies PS, Galer BS. Multicenter, double-blind, vehicle-controlled trial of long term use of lidocaine patches for postherpetic neuralgia [abstract 184]. Abstracts of the 8th World Congress of the International Association for the Study of Pain (Vancouver, British Columbia, Canada, August 17–22). 1996:274.
Ho 2008 {published data only}
Kanai 2006 {published data only}
Kanai 2009a {published data only}
Kanai 2009b {published data only}
Meier 2003 {published data only}
Rowbotham 1995 {published data only}
Rowbotham 1996 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
NCT00609323 {unpublished data only}
  • A Randomized, Double-Blind, Crossover Study Comparing Pliaglis™ (Lidocaine and Tetracaine) Cream 7%/7% to Placebo Cream When Applied for 60 Minutes in the Treatment of Patients With Postherpetic Neuralgia. http://clinicaltrials.gov/ct2/show/NCT00609323 (accessed 5 February 2014) 2014. [NCT: NCT00609323]
NCT01155986 {unpublished data only}
  • Lidocaine 5% Medicated Plaster for the Topical Treatment of Localized Chronic Postoperative Neuropathic Pain. http://clinicaltrials.gov/ct2/show/NCT01155986 (accessed 5 February 2014) 2014. [NCT: NCT01155986]
Tajti 1999 {published data only}
  • Tajti J, Szok D, Vécsei L. Topical acetylsalicylic acid versus lidocaine for postherpetic neuralgia: results of a double-blind comparative clinical trial. Neurobiology (Bp) 1999;7(2):103-8.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
NCT00904202 {unpublished data only}
  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions. http://clinicaltrials.gov/ct2/show/NCT00904202 (accessed 5 February 2014) 2014. [NCT: NCT00904202]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
EudraCT 2009-015415-41 {unpublished data only}
  • Lidocaine patches in postoperative and posttraumatic neuropathic chronic skin pain - A prospective, randomized, double-blinded, placebo-controlled, parallel, multicentre, investigator initiated study according to clinical guidelines. www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2009-015415-41 (accessed 5 February 2014) 2014. [Eudract number: 2009-015415-41]
EudraCT 2012-000347-28 {unpublished data only}
  • Efficacy and safety of lidocaine 5% medicated plaster in localized chronic post-operative neuropathic pain. www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2012-000347-28 (accessed 5 February 2014) 2014. [Eudract number: 2012-000347-28]
EudraCT 2012-003077-26 {unpublished data only}
  • Topical lidocaine for the treatment of focal peripheral neuropathic pain: response in relation to pain phenotype. www.clinicaltrialsregister.eu/ctr-search/search?query=eudract_number:2012-003077-26 (accessed 5 February 2014) 2014. [Eudract number: EudraCT 2012-003077-26]
NCT00686127 {published data only}
  • A Randomized, Double-Blind, Placebo-Controlled Trial (RDBPCT) of the Effectiveness of the Lidocaine Patch in the Management of Neuropathic Pain After Breast Cancer Surgery. ClinicalTrials.gov (accessed 5 February 2014) 2014.
NCT01752322 {published data only}
  • Efficacy and Tolerability of Lidocaine Plaster for Treatment of Long-term Local Nerve Pain. Clinical trials.gov (accessed 5 February 2014) 2014.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Apkarian 2011
Bouhassira 2008
Campbell 2002
  • Campbell BJ, Rowbotham M, Davies PS, Jacob P 3rd, Benowitz NL. Systemic absorption of topical lidocaine in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. Journal of Pharmaceutical Sciences 2002;91(5):1343-50.
Chronicle 2004
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  • Cochrane Pain, Palliative and Supportive Care Group. PaPaS author and referee guidance. http://papas.cochrane.org/sites/papas.cochrane.org/files/uploads/L%20-%20PaPaSAuthor%26RefereeGuidance.pdf (accessed 22 January 2013).
Derry 2012
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  • Moore RA, Barden J, Derry S, McQuay HJ. Managing potential publication bias. In: McQuay HJ, Kalso E, Moore RA editor(s). Systematic Reviews in Pain Research: Methodology Refined. Seattle: IASP Press, 2008:15-24. [ISBN: 978–0931092695]
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Moore 2010b
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Moore 2010c
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Moore 2010d
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Moore 2011a
  • Moore RA, Wiffen PJ, Derry S, McQuay HJ. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. Cochrane Database of Systematic Reviews 2011, Issue 3. [DOI: 10.1002/14651858.CD007938.pub2]
Moore 2011b
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Moore 2011c
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  • Wolff RF, Bala MM, Westwood M, Kessels AG, Kleijnen J. 5% lidocaine medicated plaster in painful diabetic peripheral neuropathy (DPN): a systematic review. Swiss Medical Weekly 2010;140(21-2):297-306. [DOI: smw-12995]
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Khaliq 2007