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Intervention Protocol

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Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children

  1. Natalie K Bradford1,2,*,
  2. Rachel M Edwards2,
  3. Raymond J Chan3,4

Editorial Group: Cochrane Vascular Group

Published Online: 20 FEB 2014

DOI: 10.1002/14651858.CD010996


How to Cite

Bradford NK, Edwards RM, Chan RJ. Heparin versus 0.9% sodium chloride intermittent flushing for the prevention of occlusion in long term central venous catheters in infants and children (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD010996. DOI: 10.1002/14651858.CD010996.

Author Information

  1. 1

    University of Queensland, Centre for Online Health, Brisbane, Queensland, Australia

  2. 2

    Royal Children's Hospital, Queensland Children's Cancer Centre, Brisbane, Australia

  3. 3

    Royal Brisbane and Women's Hospital, Cancer Care Services, Brisbane, Queensland, Australia

  4. 4

    Queensland University of Technology, School of Nursing and Institute of Health and Biomedical Innovation, Brisbane, Australia

*Natalie K Bradford, Centre for Online Health, University of Queensland, Herston Road, Brisbane, Queensland, 4012, Australia. n.bradford@uq.edu.au. natalie_bradford@health.qld.gov.au.

Publication History

  1. Publication Status: New
  2. Published Online: 20 FEB 2014

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This is not the most recent version of the article. View current version (23 NOV 2015)

References

Additional references

Athale 2012
  • Athale UH, Siciliano S, Cheng J, Thabane L, Chan AK. Central venous line dysfunction is an independent predictor of poor survival in children with cancer. Journal of Pediatric Hematology/Oncology 2012;34(3):188-93.
Barclay 2012
  • Barclay CA, Vonderhaar KJ, Clark EA. The development of evidence-based care recommendations to improve the safe use of anticoagulants in children. The Journal of Pediatric Pharmacology and Therapeutics 2012;17(2):155-8.
Baskin 2009
  • Baskin JL, Pui C-H, Reiss U, Wilimas JA, Metzger ML, Ribeiro RC, et al. Management of occlusion and thrombosis associated with long-term indwelling central venous catheters. The Lancet 2009;374(9684):159-69.
Bertoglio 2012
  • Bertoglio S, Solari N, Meszaros P, Vassallo F, Bonvento M, Pastorino S, et al. Efficacy of normal saline versus heparinized saline solution for locking catheters of totally implantable long-term central vascular access devices in adult cancer patients. Cancer Nursing 2012;35(4):E35-42.
Davis 2013
  • Davis MBH. Pediatric central venous catheter management: a review of current practice. Journal of the Association for Vascular Access 2013;18(2):93-8.
Fratino 2005
  • Fratino G, Molinari AC, Parodi S, Longo S, Saracco P, Castagnola E, et al. Central venous catheter-related complications in children with oncological/hematological diseases: an observational study of 418 devices. Annals of Oncology 2005;16(4):648-54.
Gonzalez 2012
Goosens 2013
  • Goosens GA, Jerome M, Janssens C, Peetermans WE, Fieuws S, Moons P, et al. Comparing normal saline versus diluted heparin to lock non-valved totally implantable venous access devices in cancer patients: a randomised, non-inferiority, open trial. Annals of Oncology 2013;24(7):1892-9.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Versions 5.1.0 [updated March 2011] The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Lee 2005
  • Lee OK, Johnston L. A systematic review for effective management of central venous catheters and catheter sites in acute care paediatric patients. Worldviews on Evidence-Based Nursing 2005;2(1):4-13, discussion 14-5.
Lopez-Briz 2010
  • Lopez-Briz E, Ruiz Garcia V, Cabello JB, Bort-Marti S, Carbonell Sanchis R, Burls A. Heparin versus 0.9% sodium chloride intermittent flushing for prevention of occlusion in central venous catheters in adults. Cochrane Database of Systematic Reviews 2010, Issue 4. [DOI: 10.1002/14651858.CD008462]
Mitchell 2009
Moher 2009
  • Moher D, Liberati A, Tezlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Annals of Internal Medicine 2009;151(4):264-9.
Monagle 2010
Revel-Rilk 2010
RevMan 2012
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
Schallom 2012
Schilling 2006
  • Schilling S, Doellman D, Hutchinson N, Jacobs BR. The impact of needleless connector device design on central venous catheter occlusion in children: a prospective, controlled trial. JPEN. Journal of Parenteral and Enteral Nutrition 2006;30(2):85-90.
Schuster 2000
Shah 2007
  • Shah PS, Kalyn A, Satodia P, Dunn MS, Parvez B, Daneman A, et al. A randomized, controlled trial of heparin versus placebo infusion to prolong the usability of peripherally placed percutaneous central venous catheters (PCVCs) in neonates: the HIP (Heparin Infusion for PCVC) study. Pediatrics 2007;119(1):e284-e91.
Stocco 2012
  • Stocco JGD, Crozeta K, Taminato M, Reichembach-Danski MT, Meier MJ. Evaluation of the mortality of neonates and children related to the use of central venous catheters: a systematic review. Acta Paulista de Enfermagem 2012;25(1):90-5.
Wong 2012
  • Wong T, Clifford V, McCallum Z, Shalley H, Peterkin M, Paxton G, et al. Central venous catheter thrombosis associated with 70% ethanol locks in pediatric intestinal failure patients on home parenteral nutrition. A case series. JPEN. Journal of Parenteral and Enteral Nutrition 2012;36(3):358-60.
Young 2008
  • Young G. New anticoagulants in children. ASH Education Program Book 2008;1:245-50.