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Effect of pre-exchange albumin infusion on neonatal hyperbilirubinaemia and long-term developmental outcomes

  1. Tao Xiong,
  2. Hongju Chen,
  3. Dezhi Mu*

Editorial Group: Cochrane Neonatal Group

Published Online: 22 FEB 2014

Assessed as up-to-date: 12 FEB 2014

DOI: 10.1002/14651858.CD011001


How to Cite

Xiong T, Chen H, Mu D. Effect of pre-exchange albumin infusion on neonatal hyperbilirubinaemia and long-term developmental outcomes (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD011001. DOI: 10.1002/14651858.CD011001.

Author Information

  1. West China Second University Hospital, Sichuan University, Department of Pediatrics, Chengdu, Sichuan, China

*Dezhi Mu, Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 17, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, 610041, China. dezhimu@yahoo.com. dezhi.mu@ucsf.edu.

Publication History

  1. Publication Status: New
  2. Published Online: 22 FEB 2014

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine the effects of pre-exchange albumin infusion on the frequency and severity of hyperbilirubinaemia, long-term neurodevelopmental outcomes, complications of exchange transfusion; and to determine the adverse effects of pre-exchange albumin infusion in infants with hyperbilirubinaemia requiring exchange transfusion.

Primary comparisons

  1. Pre-exchange albumin infusion plus exchange transfusion versus exchange transfusion alone. Phototherapy may or may not be given in the trials.
  2. Subgroup analyses based on gestational age (term infant (≥ 37 weeks) versus preterm infant (< 37 weeks)), causes of jaundice (haemolytic disease versus non-haemolytic disease), dose of albumin, volume of exchange transfusion, and associated medical therapy (phototherapy, metalloporphyrins, barbiturates, charcoal, cholestyramine, clofibrate, D-penicillamine, glycerin, manna, riboflavin, traditional Chinese medicine, homeopathy and agar, which are used before albumin infusion).