Intervention Protocol

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High flow nasal cannula for respiratory support in term infants

  1. Sara Mayfield1,2,3,*,
  2. Jacqueline Jauncey-Cooke1,2,3,
  3. Andreas Schibler1,3,
  4. Judith L Hough1,3,4,
  5. Fiona Bogossian2

Editorial Group: Cochrane Neonatal Group

Published Online: 4 MAR 2014

Assessed as up-to-date: 21 FEB 2014

DOI: 10.1002/14651858.CD011010

How to Cite

Mayfield S, Jauncey-Cooke J, Schibler A, Hough JL, Bogossian F. High flow nasal cannula for respiratory support in term infants (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD011010. DOI: 10.1002/14651858.CD011010.

Author Information

  1. 1

    Mater Children’s Hospital, Paediatric Critical Care Research Group, South Brisbane, Queensland, Australia

  2. 2

    School of Nursing and Midwifery, The University of Queensland, Herston, Australia

  3. 3

    Mater Research Institute, South Brisbane, Australia

  4. 4

    Australian Catholic University, School of Physiotherapy, Banyo, Australia

*Sara Mayfield, Paediatric Critical Care Research Group, Mater Children’s Hospital, South Brisbane, Queensland, 4101, Australia.

Publication History

  1. Publication Status: New
  2. Published Online: 4 MAR 2014



Additional references

ARDS Network 2000
  • The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. New England Journal of Medicine 2000;342(18):1301-8.
Beggs 2014
Campbell 2006
Corley 2012
  • Corley A, Rickard CM, Aitken LM, Johnston A, Barnett A, Fraser JF. High flow nasal cannulae for respiratory support in adult intensive care patients. Cochrane Database of Systematic Reviews 2012, Issue 11. [DOI: 10.1002/14651858.CD010172]
Dahlem 2003
  • Dahlem P, van Aslderen WM, Hamaker ME, Dijkfraaf MG, Bos AP. Incidence and short-term outcome of acute lung injury in mechanically ventilated children. European Respiratroy Journal 2003;22(6):980-5.
de Klerk 2008
  • de Klerk A. Humidified high-flow nasal cannula: is it the new and improved CPAP?. Advances in Neonatal Care 2008;8(2):98-106.
Dysart 2009
Frey 2001
Hedge 2013
  • Hedge S, Prodhan P. Serious air leak syndrome complicating high-flow nasal cannula therapy. Pediatrics 2013;131(3):e939-e944.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Lampland 2009
  • Lampland A, Plumm B, Meyers P, Worwa C, Mammel M. Observational study of humidified high-flow nasal cannula compared with nasal continuous positive airway pressure. Journal of Pediatrics 2009;154(2):177-82.
Mayfield 2012
  • Mayfield S, Jauncey-Cooke J, Hough JL, Schibler A, Gibbons K, Bogossian F. High flow nasal cannula therapy for respiratory support in children. Cochrane Database of Systematic Reviews 2012, Issue 5. [DOI: 10.1002/14651858.CD009850]
McKiernan 2010
Reid 1984
Review Manager 2013 [Computer program]
  • Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.2. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2013.
Roca 2010
  • Roca O, Riera J, Torres F, Masclans J. High-flow oxygen therapy in acute respiratory failure. Respiratory Care 2010;55(4):408-13.
Saslow 2006
Schibler 2011
  • Schibler A, Pham T, Dunster K, Forster K, Barlow A, Gibbons K, et al. Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery. Intensive Care Medicine 2011;37(5):847-52.
Screenan 2001
  • Sreenan C, Lemke RP, Hudson-Mason A, Osiovich H. High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure. Pediatrics 2001;107(5):1081-3.
Shoemaker 2007
  • Shoemaker MT, Pierce MR, Yoder BA, DiGeronimo RJ. High flow nasal cannula versus nasal CPAP for neonatal respiratory disease: a retrospective study. Journal of Perinatology 2007;27(2):85-91.
Spence 2007
  • Spence KL, Murphy D, Kilian C, McGonigle R, Kilani RA. High-flow nasal cannula as a device to provide continuous positive airway pressure in infants. Journal of Perinatology 2007;27(12):772-5.
Spentzas 2009
  • Spentzas T, Minarik M, Patters AB, Vinson B, Stidham G. Children with respiratory distress treated with high-flow nasal cannula. Journal of Intensive Care Medicine 2009;24(5):323-8.
Sutton 2008
Thorsteinsson 2002
Wilkinson 2011
Wing 2012
  • Wing R, James C, Maranda L, Armsby C. Use of high-flow nasal cannula support in the emergency department reduces the need for intubation in paediatric acute respiratory insufficiency. Pediatric Emergency Care 2012;28(11):1117-23.
Yong 2005
  • Yong SC, Chen SJ, Boo NY. Incidence of nasal trauma associated with nasal prong versus nasal mask during continuous positive airway pressure in very low birthweight infants: a randomised control study. Archives of Diseases in Chilhood. Fetal and Neonatal Edition. 2005;90(6):F480-3.