Intervention Protocol

Chemotherapy, radiotherapy, chemoradiotherapy and combination therapy in localised and locally advanced pancreatic cancer

  1. Asma Sultana1,*,
  2. Richard J Jackson2,
  3. Trevor Cox3,
  4. Daniel Palmer1,
  5. John Neoptolemos1,
  6. Paula Ghaneh1

Editorial Group: Cochrane Upper Gastrointestinal and Pancreatic Diseases Group

Published Online: 5 AUG 2014

DOI: 10.1002/14651858.CD011044


How to Cite

Sultana A, Jackson RJ, Cox T, Palmer D, Neoptolemos J, Ghaneh P. Chemotherapy, radiotherapy, chemoradiotherapy and combination therapy in localised and locally advanced pancreatic cancer (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 8. Art. No.: CD011044. DOI: 10.1002/14651858.CD011044.

Author Information

  1. 1

    University of Liverpool, Department of Molecular and Clinical Cancer Medicine, Liverpool, UK

  2. 2

    Liverpool University, North West Surgical Trials Centre, Liverpool, UK

  3. 3

    University of Liverpool, Liverpool Cancer Research UK Cancer Trials Unit, Liverpool, UK

*Asma Sultana, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK. asultana@liv.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 5 AUG 2014

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

A systematic review of the available evidence, both published and unpublished, on the management of localised and locally advanced pancreatic cancer is planned. The interventions to be evaluated are chemotherapy and radiotherapy, in the adjuvant (for localised pancreatic cancer), neoadjuvant (for localised and locally advanced pancreatic cancer) and palliative settings (for locally advanced pancreatic cancer). We will study chemotherapy administered either as single agent or as combination therapy, including with novel agents. We will assess radiotherapy, given either alone or combined with chemotherapy as chemoradiation, chemoradiation followed on by chemotherapy or chemotherapy with follow-on chemoradiation.