This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:
To determine whether the use of prophylactic calcium reduces the risk of hypocalcaemia-related morbidities and death among newborn infants receiving EBT.
We will perform subgroup analysis to address:
preterm (< 37 weeks gestation) versus term (≥ 37 weeks gestation);
the type of anticoagulant in the blood transfused (comparison will be made between citrate and heparin);
the volume of blood used (comparison will be made between single-volume and double-volume EBT);
timing of administration of calcium (comparison will be made between administration during EBT or administration immediately after EBT).