Prophylactic intravenous calcium therapy for exchange blood transfusion in the newborn

  • Protocol
  • Intervention

Authors

  • Tinuade A Ogunlesi,

    Corresponding author
    1. Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Department of Paediatrics (Neonatal Unit), Sagamu, Ogun State, Nigeria
    • Tinuade A Ogunlesi, Department of Paediatrics (Neonatal Unit), Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, 121001NG, Nigeria. tinuade_ogunlesi@yahoo.co.uk.

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  • Foluso EA Lesi

    1. College of Medicine of the University of Lagos, Department of Paediatrics, Lagos, Nigeria
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Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

Primary

To determine whether the use of prophylactic calcium reduces the risk of hypocalcaemia-related morbidities and death among newborn infants receiving EBT.

Secondary

We will perform subgroup analysis to address:

  1. preterm (< 37 weeks gestation) versus term (≥ 37 weeks gestation);

  2. the type of anticoagulant in the blood transfused (comparison will be made between citrate and heparin);

  3. the volume of blood used (comparison will be made between single-volume and double-volume EBT);

  4. timing of administration of calcium (comparison will be made between administration during EBT or administration immediately after EBT).