This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:
To assess the efficacy of proton pump inhibitors for the global symptoms of functional dyspepsia, or epigastric pain/discomfort pain if global symptoms are not reported.
To evaluate the effect of treatment on different functional dyspepsia symptoms (e.g. reflux, epigastric pain, nausea), as well as the effect on quality of life and adverse events.