Paracetamol (acetaminophen) for prevention or treatment of pain in newborns

  • Protocol
  • Intervention

Authors

  • Arne Ohlsson,

    Corresponding author
    1. University of Toronto, Departments of Paediatrics, Obstetrics and Gynaecology and Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada
    • Arne Ohlsson, Departments of Paediatrics, Obstetrics and Gynaecology and Institute of Health Policy, Management and Evaluation, University of Toronto, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. aohlsson@mtsinai.on.ca.

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  • Prakeshkumar S Shah

    1. University of Toronto Mount Sinai Hospital, Department of Paediatrics and Health Policy, Management and Evaluation, Toronto, ON, Canada
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective

To determine the efficacy and safety of paracetamol for the prevention or treatment of procedural/postoperative pain or pain associated with clinical conditions in neonates.

Secondary objective

To review the effect of the various doses and routes of administration (enteral,intravenous or rectal) of paracetamol for the prevention or treatment of pain in neonates. We will design the main comparisons according to intention of use: paracetamol for the prevention or treatment of pain. We will include separate comparisons based on the painful intervention/procedure/condition (heel lance, insertion of nasogastric tube, insertion of intravenous catheter, lumbar puncture, postoperative pain, birth trauma, congenital anomalies (myelomeningocoele, open cutaneous lesions)) and the mode of administration of paracetamol. Within these comparisons we will assess in subgroups (when possible) the effects based on postmenstrual age (PMA) at birth of the randomised infants (under 28 weeks, 28 weeks to less than 32 weeks, 32 weeks to less than 37 weeks and 37 weeks or more) or based on birth weight (or current weight) categories (1000 g or less, 1001 g to 1500 g, 1501 g to 2500 g and 2501 g or more).