This is the protocol for a review and there is no abstract. The objectives are as follows:
To determine the efficacy and safety of paracetamol for the prevention or treatment of procedural/postoperative pain or pain associated with clinical conditions in neonates.
To review the effect of the various doses and routes of administration (enteral,intravenous or rectal) of paracetamol for the prevention or treatment of pain in neonates. We will design the main comparisons according to intention of use: paracetamol for the prevention or treatment of pain. We will include separate comparisons based on the painful intervention/procedure/condition (heel lance, insertion of nasogastric tube, insertion of intravenous catheter, lumbar puncture, postoperative pain, birth trauma, congenital anomalies (myelomeningocoele, open cutaneous lesions)) and the mode of administration of paracetamol. Within these comparisons we will assess in subgroups (when possible) the effects based on postmenstrual age (PMA) at birth of the randomised infants (under 28 weeks, 28 weeks to less than 32 weeks, 32 weeks to less than 37 weeks and 37 weeks or more) or based on birth weight (or current weight) categories (1000 g or less, 1001 g to 1500 g, 1501 g to 2500 g and 2501 g or more).