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Unprecedented Regiocontrol Using An Aldolase I Antibody

  1. Virginie Maggiotti1,
  2. Marina Resmini Dr.2,
  3. Véronique Gouverneur Dr.1

Article first published online: 15 MAR 2002

DOI: 10.1002/1521-3757(20020315)114:6<1054::AID-ANGE1054>3.0.CO;2-H

Issue

Angewandte Chemie

Angewandte Chemie

Volume 114, Issue 6, pages 1054–1056, March 15, 2002

Additional Information

How to Cite

Maggiotti, V., Resmini, M. and Gouverneur, V. (2002), Unprecedented Regiocontrol Using An Aldolase I Antibody . Angew. Chem., 114: 1054–1056. doi: 10.1002/1521-3757(20020315)114:6<1054::AID-ANGE1054>3.0.CO;2-H

Author Information

  1. 1

    University of Oxford The Dyson Perrins Laboratory South Parks Road, Oxford OX1 3QY (UK) Fax: (+44) 1865-275-644

  2. 2

    Queen Mary, University of London Department of Chemistry Mile End Road, London E1 4NS (UK)

  1. This work was supported by the University of Oxford (grant B(RE)9862 to V.G. and grant to V.M.) and the Royal Society of Chemistry (RSRG 20750 grant to V.G.). We thank Professor R. A. Lerner for supplying a very generous quantity of antibody 84G3.

Publication History

  1. Issue published online: 15 MAR 2002
  2. Article first published online: 15 MAR 2002
  3. Manuscript Received: 24 OCT 2001

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Keywords:

  • Aldolreaktionen;
  • Asymmetrische Katalyse;
  • Katalytische Antikörper;
  • Regioselektivität
Thumbnail image of graphical abstract

Direkte asymmetrische Aldolreaktionen am weniger substituierten Kohlenstoffatom unmodifizierter unsymmetrischer Ketone gelingen in Gegenwart des kommerziell erhältlichen Aldolase-I-Antikörpers 84G3 [Gl. (1)]. Bei allen Reaktionen war der Enantiomerenüberschuss größer als 94 %. Indem entweder die Aldol- oder die Retro-Aldolreaktion genutzt wird, sind beide Enantiomere zugänglich.

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