41:19<>1.0.CO;2-E/asset/cover.gif?v=1&s=996ae6360e88b8ec019d239629b5174badb0777a "Angewandte Chemie International Edition")
These authors contributed equally to this work.
1521-3773/asset/2002_left.gif?v=1&s=ac6b0d94a94d7ce7a210002b8096b42feffc0bcf)
1521-3773/asset/2002_right.gif?v=1&s=451042aa3415ae3ad0729984d26dee1866aca82e)
Communication
Kinetics of a Reversible Covalent-Bond-Forming Reaction Observed at the Single-Molecule Level†
Article first published online: 4 OCT 2002
DOI: 10.1002/1521-3773(20021004)41:19<3707::AID-ANIE3707>3.0.CO;2-5
© 2002 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Shin, S.-H., Luchian, T., Cheley, S., Braha, O. and Bayley, H. (2002), Kinetics of a Reversible Covalent-Bond-Forming Reaction Observed at the Single-Molecule Level. Angew. Chem. Int. Ed., 41: 3707–3709. doi: 10.1002/1521-3773(20021004)41:19<3707::AID-ANIE3707>3.0.CO;2-5
- †
The authors acknowledge grants from the U.S. Department of Energy, the Multidisciplinary University Research Initiative (1999), the National Institutes of Health, the Office of Naval Research and the Texas Advanced Technology Program.
Publication History
- Issue published online: 4 OCT 2002
- Article first published online: 4 OCT 2002
- Manuscript Received: 8 JUL 2002
Keywords:
- analytical methods;
- arsenic;
- protein structures;
- single-molecule studies;
- sulfur
41:19<3707::AID-ANIE3707>3.0.CO;2-5/asset/image_m/mcontent.gif?v=1&s=5b3de194037d29a59d72cddbe2112c26d1cca3f0 "Thumbnail image of graphical abstract")
Arsenic, currents, and pores: Reversible covalent-bond-forming reactions are monitored by single-molecule detection. One reactant, a thiol group, is present on the wall of a protein pore, while the second, an organoarsenic(III) compound is in solution (see scheme). The reaction is detected by observing the current flowing through the pore (see trace), which allows the determination of rate constants with microsecond time resolution.