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This work was financially supported by a Grant-in-Aid for Scientific Research (No. 07CE2004) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
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Communication
CH/π Attraction: The Origin of Enantioselectivity in Transfer Hydrogenation of Aromatic Carbonyl Compounds Catalyzed by Chiral η6-Arene-Ruthenium(II) Complexes
Article first published online: 2 AUG 2001
DOI: 10.1002/1521-3773(20010803)40:15<2818::AID-ANIE2818>3.0.CO;2-Y
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
Additional Information
How to Cite
Yamakawa, M., Yamada, I. and Noyori, R. (2001), CH/π Attraction: The Origin of Enantioselectivity in Transfer Hydrogenation of Aromatic Carbonyl Compounds Catalyzed by Chiral η6-Arene-Ruthenium(II) Complexes . Angew. Chem. Int. Ed., 40: 2818–2821. doi: 10.1002/1521-3773(20010803)40:15<2818::AID-ANIE2818>3.0.CO;2-Y
Publication History
- Issue published online: 2 AUG 2001
- Article first published online: 2 AUG 2001
- Manuscript Revised: 29 MAY 2001
- Manuscript Received: 9 AUG 2000
Keywords:
- asymmetric synthesis;
- CH/π interactions;
- density functional calculations;
- hydrogenation;
- ruthenium
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The through-space CH/π attraction between the η6-arene ligand on Ru and the carbonyl aryl substituent (see transition states in picture) plays a key role in the enantioselective transfer hydrogenation of aromatic carbonyl compounds with 2-propanol or formic acid, catalyzed by chiral η6-arene–RuII complexes.