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Keywords:

  • aldol reaction;
  • enzyme catalysis;
  • epothilones;
  • synthetic methods;
  • total synthesis
Thumbnail image of graphical abstract

Enzymatic reactions catalyzed by DERA provide the basis for a new strategy for the synthesis of novel pyranose synthons. The utility of this very convergent and effective method is demonstrated by the concise total synthesis of epothilones (see scheme; DERA=2-deoxyribose-5-phosphate aldolase).