SEARCH

SEARCH BY CITATION

Keywords:

  • cyanohydrins;
  • enzyme catalysis;
  • ketones;
  • lyases;
  • molecular modeling
Thumbnail image of graphical abstract

The choice of enzyme is decisive: for the enzyme-catalyzed addition of HCN to 4-substituted cyclohexanones 1, highly selective biocatalysts are available that allow control to yield the cis or the trans addition product 2. Modeling of the S enzyme–substrate complex reveals remarkable parallels with the Prelog/Ringold model of the LADH-catalyzed hydrogenation of cyclohexanones.