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Feature Article
Comparison of Voltammetry Assisted by Multivariate Analysis with EXAFS as Applied to the Study of Cd- and Zn-Binding of Metallothionein Related Peptides
Article first published online: 16 JUL 2002
DOI: 10.1002/1521-4109(200207)14:13<899::AID-ELAN899>3.0.CO;2-8
© 2002 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany
1521-4109/asset/cover.gif?v=1&s=209b447dcf920ba3fb44f2b08a87a6b586320422 "Electroanalysis")
Additional Information
How to Cite
Díaz-Cruz, M. S., Díaz-Cruz, J. M. and Esteban, M. (2002), Comparison of Voltammetry Assisted by Multivariate Analysis with EXAFS as Applied to the Study of Cd- and Zn-Binding of Metallothionein Related Peptides. Electroanalysis, 14: 899–905. doi: 10.1002/1521-4109(200207)14:13<899::AID-ELAN899>3.0.CO;2-8
Publication History
- Issue published online: 16 JUL 2002
- Article first published online: 16 JUL 2002
- Manuscript Accepted: 31 OCT 2001
- Manuscript Received: 26 JUL 2001
- Abstract
- References
- Cited By
Keywords:
- Voltammetry;
- EXAFS;
- Multivariate analysis;
- Glutathione;
- Metallothionein related peptides;
- Cadmium;
- Zinc
Abstract
Zn- and Cd-complexes of glutathione (GSH) and the metallothionein related peptide Lys-Cys-Thr-Cys-Cys-Ala (FT) were investigated by EXAFS and by voltammetry, assisted by multivariate curve resolution (MCR). EXAFS data from the Zn-FT system seem to show the formation in low extent (under 50%) of a metal cluster with a coordination number of four. In the cases of Cd-FT, Zn-GSH and Cd-GSH no sound conclusions can be deduced from EXAFS. These results are in contrast with those found by voltammetric techniques. The use of MCR allows to calculate the voltammograms corresponding to each single process and its corresponding concentration profile. Then models of complexation are proposed.