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  • 1
    Medzhitov, R., Preston-Hurlburt, P. and Janeway, C. A. Jr., A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997. 388: 394397.
  • 2
    Medzhitov, R. and Janeway, C. A. Jr., Innate immunity. N. Engl. J. Med. 2000. 343: 338344.
  • 3
    Aderem, A. and Ulevitch, R. J., Toll-like receptors in the induction of the innate immune response. Nature 2000. 406: 782787.
  • 4
    Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., Freudenberg, M., Ricciardi-Castagnoli, P., Layton, B. and Beutler, B., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998. 282: 20852088.
  • 5
    Aliprantis, A. O., Yang, R. B., Mark, M. R., Suggett, S., Devaux, B., Radolf, J. D., Klimpel, G. R., Godowski, P. and Zychlinsky, A., Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2. Science 1999. 285: 736739.
  • 6
    Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A., Wilson, C. B., Bassetti, M. and Aderem, A., The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999. 401: 811815.
  • 7
    Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M. and Aderem, A., The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001. 410: 10991103.
  • 8
    Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. and Akira, S., A Toll-like receptor recognizes bacterial DNA. Nature 2000. 408: 740745.
  • 9
    Bauer, S., Kirschning, C. J., Hacker, H., Redecke, V., Hausmann, S., Akira, S., Wagner, H. and Lipford, G. B., Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 2001. 98: 92379242.
  • 10
    Medzhitov, R., Preston-Hurlburt, P., Kopp, E., Stadlen, A., Chen, C., Ghosh, S. and Janeway, C. A. Jr., MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 1998. 2: 253258.
  • 11
    Muzio, M., Natoli, G., Saccani, S., Levrero, M. and Mantovani, A., The human Toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 1998. 187: 20972101.
  • 12
    Muzio, M., Ni, J., Feng, P. and Dixit, V. M., IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997. 278: 16121615.
  • 13
    Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. and Cao, Z., MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 1997. 7: 837847.
  • 14
    Wesche, H., Gao, X., Li, X., Kirschning, C. J., Stark, G. R. and Cao, Z., IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J. Biol. Chem. 1999. 274: 1940319410.
  • 15
    Cao, Z., Henzel, W. J. and Gao, X., IRAK: a kinase associated with the interleukin-1 receptor. Science 1996. 271: 11281131.
  • 16
    Baud, V., Liu, Z. G., Bennett, B., Suzuki, N., Xia, Y. and Karin, M., Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999. 13: 12971308.
  • 17
    Häcker, H., Vabulas, R. M., Takeuchi, O., Hoshino, K., Akira, S. and Wagner, H., Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 2000. 192: 595600.
  • 18
    Schnare, M., Holt, A. C., Takeda, K., Akira, S. and Medzhitov, R., Recognition of CpG DNA is mediated by signaling pathways dependent on the adaptor protein MyD88. Curr. Biol. 2000. 10: 11391142.
  • 19
    Underhill, D. M., Ozinsky, A., Smith, K. D. and Aderem, A., Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc. Natl. Acad. Sci. USA 1999. 96: 1445914463.
  • 20
    Horng, T., Barton, G. M. and Medzhitov, R., TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2001. 2: 835841.
  • 21
    Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T., McMurray, D., Smith, D. E., Sims, J. E., Bird, T. A. and O'Neill, L. A., Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 2001. 413: 7883.
  • 22
    Ozinsky, A., Underhill, D. M., Fontenot, J. D., Hajjar, A. M., Smith, K. D., Wilson, C. B., Schroeder, L. and Aderem, A., The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. USA 2000. 97: 1376613771.
  • 23
    Yoshimori, T., Yamamoto, A., Moriyama, Y., Futai, M. and Tashiro, Y., Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells. J. Biol. Chem. 1991. 266: 1770717712.
  • 24
    Häcker, H., Mischak, H., Miethke, T., Liptay, S., Schmid, R., Sparwasser, T., Heeg, K., Lipford, G. B. and Wagner, H., CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 1998. 17: 62306240.
  • 25
    Yi, A. K., Peckham, D. W., Ashman, R. F. and Krieg, A. M., CpG DNA rescues B cells from apoptosis by activating NFkappaB and preventing mitochondrial membrane potential disruption via a chloroquine-sensitive pathway. Int. Immunol. 1999. 11: 20152024.
  • 26
    Yi, A. K., Tuetken, R., Redford, T., Waldschmidt, M., Kirsch, J. and Krieg, A. M., CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species. J.Immunol. 1998. 160: 47554761.
  • 27
    Häcker, H., Vabulas, R. M., Takeuchi, O., Hoshino, K., Akira, S. and Wagner, H., Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 2000. 192: 595600.
  • 28
    Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K. and Akira, S., Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 2001. 166: 56885694.
  • 29
    Kaisho, T. and Akira, S., Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol. 2001. 22: 7883.
  • 30
    Tokunaga, T., Yano, O., Kuramoto, E., Kimura, Y., Yamamoto, T., Kataoka, T. and Yamamoto, S., Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol. 1992. 36: 5566.
  • 31
    Krieg, A. M., The role of CpG motifs in innate immunity. Curr. Opin. Immunol. 2000. 12: 3543.
  • 32
    Karlsson, K. and Carlsson, S. R., Sorting of lysosomal membrane glycoproteins lamp-1 and lamp-2 into vesicles distinct frommannose 6-phosphate receptor/gamma-adaptin vesicles at the trans-Golgi network. J. Biol. Chem. 1998. 273: 1896618973.
  • 33
    Ip, Y. T. and Davis, R. J., Signal transduction by the c-Jun N-terminal kinase (JNK)–from inflammation to development. Curr. Opin. Cell Biol. 1998. 10: 205219.
  • 34
    Hambleton, J., Weinstein, S. L., Lem, L. and DeFranco, A. L., Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc. Natl. Acad. Sci. USA 1996. 93: 27742778.
  • 35
    Han, J., Lee, J. D., Tobias, P. S. and Ulevitch, R. J., Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J. Biol. Chem. 1993. 268: 2500925014.
  • 36
    Han, J., Lee, J. D., Bibbs, L. and Ulevitch, R. J., A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994. 265: 808811.
  • 37
    Häcker, H., Mischak, H., Häcker, G., Eser, S., Prenzel, N., Ullrich, A. and Wagner, H., Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells. EMBO J. 1999. 18: 69736982.
  • 38
    Nomura, F., Akashi, S., Sakao, Y., Sato, S., Kawai, T., Matsumoto, M., Nakanishi, K., Kimoto, M., Miyake, K., Takeda, K. and Akira, S., Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J. Immunol. 2000. 164: 34763479.
  • 39
    Davies, P. J., Davies, D. R., Levitzki, A., Maxfield, F. R., Milhaud, P., Willingham, M. C. and Pastan, I. H., Transglutaminase is essential in receptor-mediated endocytosis of alpha 2-macroglobulin and polypeptide hormones. Nature 1980. 283: 162167.
  • 40
    Stenmark, H., Parton, R. G., Steele-Mortimer, O., Lutcke, A., Gruenberg, J. and Zerial, M., Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J. 1994. 13: 12871296.
  • 41
    Stenmark, H., Valencia, A., Martinez, O., Ullrich, O., Goud,B. and Zerial, M., Distinct structural elements of rab5 define its functional specificity. EMBO J. 1994. 13: 575583.
  • 42
    Chavrier, P., Parton, R. G., Hauri, H. P., Simons, K. and Zerial, M., Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments. Cell 1990. 62: 317329.
  • 43
    Nielsen, E., Severin, F., Backer, J. M., Hyman, A. A. and Zerial, M., Rab5 regulates motility of early endosomes on microtubules. Nat. Cell Biol. 1999. 1: 376382.
  • 44
    Sato, S., Nomura, F., Kawai, T., Takeuchi, O., Muhlradt, P. F., Takeda, K. and Akira, S., Synergy and cross-tolerance between Toll-like receptor (TLR) 2- and TLR4-mediated signalingpathways. J. Immunol. 2000. 165: 70967101.
  • 45
    Kitchens, R. L., Wang, P. and Munford, R. S., Bacterial lipopolysaccharide can enter monocytes via two CD14-dependent pathways. J. Immunol. 1998. 161: 55345545.
  • 46
    Thieblemont, N. and Wright, S. D., Transport of bacterial lipopolysaccharide to the Golgi apparatus. J. Exp. Med. 1999. 190: 523534.
  • 47
    Kirschning, C. J., Wesche, H., Merrill, A. T. and Rothe, M., Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 1998. 188: 20912097.
  • 48
    Takeshita, F., Leifer, C. A., Gursel, I., Ishii, K. J., Takeshita, S., Gursel, M. and Klinman, D. M., Cutting edge: role of toll-like receptor 9 in cpg dna-induced activation of human cells. J. Immunol. 2001. 167: 35553558.
  • 49
    Assenmacher, M., Lohning, M., Scheffold, A., Richter, A., Miltenyi, S., Schmitz, J. and Radbruch, A., Commitment of individual Th1-like lymphocytes to expression of IFN-gamma versusIL-4 and IL-10: selective induction of IL-10 by sequential stimulation of naive Th cells with IL-12 and IL-4. J. Immunol. 1998. 161: 28252832.